Abstract: Objective　To investigate the clinical characteristics, susceptibility factors, and prognostic factors of severe acute appendicitis complicated with septic shock, and to provide references for the treatment of this kind of disease. Methods　The data of the patients who underwent laparoscopic acute appendicitis resection from October 2013 to October 2021 at Department of General Surgery, Shenzhen Bao 'an District People's Hospital were retrospectively collected. The patients with acute appendicitis and septic shock were set as an observation group, and the patients with acute appendicitis and matched baseline data were set as a control group. The general conditions, clinical characteristics, inflammatory indicators, and prognostic factors were compared between the two groups by χ² test and t test. Results　The observation group had 17 cases and 9 males (52.94%) and were (33.2±3.41) years old. The control group had 100 cases and 59 males (59.00%) and were (32.1±3.30) years old. In the observation group, all the 17 patients were cured and discharged without death. Three patients had postoperative incision infection (17.65%) and 5 postoperative fever(29.41%), and 4 postoperative gangrene (23.53%) in the observation group, and 2 (2.00%, 2/100) had postoperative incision infection, 3 (3.00%)postoperative fever and 1 (1.00%, 1/100) postoperative gangrene in the control group, with statistical differences (χ²=11.612, 8.895, 13.725, P=0.109, 0.003, <0.001). The observation group had longer operation time and hospital stay and higher percentages of drinking white blood cells, and neutrophils, procalcitonin, and a rate of gangrene than the control group, with statistical differences between the two groups (all P < 0.05). There were no statistical differences in age, gender, smoking, liver function between the two groups (all P > 0.05). Conclusions　Patients with acute appendicitis and septic shock have a long disease course, high levels of inflammatory indicators, and dangerous conditions. Clinicians should pay attention to it and choose surgical treatment as soon as possible.

Key words: Acute appendicitis, Septic shock, Appendicitis incision infection

摘要： 目的　探讨伴有感染性休克的急性阑尾炎临床特点、易感因子及预后相关因素，为此类疾病的治疗提供参考依据和借鉴。方法　回顾性收集整理南方医科大学附属深圳宝安人民医院普通外科2013年10月至2021年10月8年内行腹腔镜急性阑尾炎切除手术的患者资料。将伴有感染性休克的急性阑尾炎患者作为观察组，另取基线资料匹配的单纯性急性阑尾炎手术患者作为对照组。使用χ²和t检验比较两组患者一般情况、临床特点、炎性指标、预后相关因素等方面的差异。结果　观察组17例，年龄为（33.2±3.41）岁，男9例（52.94%）；对照组100例，年龄为（32.1±3.30）岁，男59例（59.00%）。观察组17例全部治愈出院，无死亡患者。观察组术后切口感染发生率为17.65%（3/17），术后发热29.41%（5/17），术后坏疽发生率23.53%（4/17），对照组分别为2.00%（2/100）、3.00%（3/100）、1.00%（1/100），两组比较，差异均有统计学意义（χ²=11.612、8.895、13.725，P=0.109、0.003、<0.001）。另外，观察组的患者手术与住院时间长，饮酒、白细胞计数、中性粒细胞计数、降钙素原及发生坏疽的概率较高，两组比较差异均有统计学意义（均P<0.05）；而年龄、性别、吸烟、肝功能两组比较差异均无统计学意义（均P>0.05）。结论　伴有感染性休克的急性阑尾炎患者病程长、炎性指标高，病情凶险，临床医生应重视，并尽早选择手术治疗。

关键词: 急性阑尾炎, 感染性休克, 阑尾炎切口感染