Type 2 diabetes increases the risk of preeclampsia through alterations in gut microbiota

doi:10.3760/cma.j.cn441417-20250306-10001

Abstract

Abstract:

Objective　To analyze the potential role of gut microbiota in elevating the risk of preeclampsia in individuals with diabetes by Mendelian randomization (MR). Methods　The study was carried out at Yantaishan Hospital from September to November 2024. The data of Genome-Wide Association Studies (GWAS) extracted from the IEU OpenGWAS public database. This study analyzed three large diabetic cohorts (n=461 578, 520 580, and 659 316), along with preeclampsia (n=118 291) and eclampsia (n=11 729) cohorts. The two-step MR method was employed to evaluate the mediating effect of gut microbiota on the relationship between diabetes and preeclampsia. Additionally, the GWAS data for gut microbiota included 211 taxa derived from 14 306 European participants. The MR-Egger regression intercept and Cochran's Q were used to evaluate the pleiotropy and heterogeneity. The sensitivity was analyzed by the leave-one-out method. Results　Types 1 and 2 diabetes were both associated with increased risk of preeclampsia (OR=1.05 and 1.15). Among the 211 gut microbiota taxa analyzed, the effect values of Olsenella for preeclampsia was 0.12 (P=0.003); the effect value of type 2 diabetes for preeclampsia was 0.14 (P=8.23E-05). Olsenella was related to type 2 diabetes and preeclampsia. The MR indicated that Olsenella partially mediated the effect of type 2 diabetes on preeclampsia, accounting for 6% of the total effect. Conclusion　Type 2 diabetes may increase the risk of preeclampsia via gut microbiota.

Key words: Type 2 diabetes, Preeclampsia, Gut microbiota, Mendelian randomization

摘要：

目的　采用孟德尔随机化分析肠道菌群在糖尿病增加子痫前期风险中的中介作用。方法　本研究于2024年9月至11月在烟台市烟台山医院进行。从IEU OpenGWAS公开数据库中提取全基因组关联研究（Genome-Wide Association Studies，GWAS）数据，包括糖尿病（分别来自3个队列，样本量分别为461 578例、520 580例、659 316例）、子痫前期（118 291例）和子痫（11 729例）患者的单核苷酸多态性。使用两步法孟德尔随机化评估肠道菌群在糖尿病与子痫前期关系中的介导作用。211种肠道菌群的GWAS数据来自于14 306名欧洲参与者。采用MR-Egger回归截距和Cochran'sQ评估多效性和异质性，留一法进行敏感性分析。结果　1型糖尿病、2型糖尿病均与子痫前期风险增加相关［比值比（OR）=1.05、1.15］。在211种肠道菌群中，奥尔森菌属对子痫前期的效应值为0.12（P=0.003）；2型糖尿病对子痫前期的效应值为0.14（P=8.23E-05），奥尔森菌属与2型糖尿病、子痫前期均相关。孟德尔随机化显示，奥尔森菌属介导2型糖尿病对子痫前期风险有促进作用，占总效应的6%。结论　2型糖尿病通过肠道菌群增加子痫前期的发病风险。

关键词: 2型糖尿病； , , 子痫前期； , , 肠道菌群； , , 孟德尔随机化

Yang Haiyan, Song Qinwen, Wang Shili, Lyu Shangling, Chen Xiaofang, Qin Ying.

Type 2 diabetes increases the risk of preeclampsia through alterations in gut microbiota [J]. International Medicine and Health Guidance News, 2025, 31(10): 1586-1591.

杨海燕宋沁雯王世丽吕尚伶陈晓芳秦莹. #br# 2型糖尿病通过影响肠道菌群增加子痫前期的风险 #br# [J]. 国际医药卫生导报, 2025, 31(10): 1586-1591.

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