Abstract:

Objective　To explore the application effect of personalized care plans for children's autoimmune diseases (AD) based on the concept of precision medicine. Methods　From March 2022 to March 2024, 120 children with AD who visited Henan Provincial People's Hospital were selected for a randomized controlled trial. They were divided into the study group and the control group using a random number table, with 60 cases in each group.In the control group, there were 31 males and 29 females, with an average age of (9.04±1.39) years. They received routine care.The research group consisted of 35 males and 25 females, with an average age of (9.36±1.87) years. On the basis of the control group, personalized care based on the concept of precision medicine was implemented.Both groups received 1 month of nursing care and were followed up for 6 months.Compare the levels of medical fear, treatment compliance, self-management ability, as well as the satisfaction of family members with the care provided and the recurrence frequency after discharge of the two groups of children before and after the nursing process.Statistical methods employed t-test and χ² test. Results　After the nursing intervention, the medical fear score of the children in the study group was lower than that of the control group [(4.67±0.81) points vs. (5.99±0.95) points], and the difference was statistically significant (t=8.190, P<0.05).The scores of treatment compliance, self-management ability, and family satisfaction with care of the children in the study group were significantly higher than those in the control group [(90.85±7.02) points vs. (87.59±5.92) points, (78.85±4.05) points vs. (76.74±4.16) points, 91.67%(55/60) vs. 71.67%(43/60)], and the differences were statistically significant (t=2.75 and 2.815, χ²=8.015, all P<0.05).The recurrence frequency of the study group's children within 3 months and 6 months after discharge was lower than that of the control group [(4.00±0.67) times vs. (4.59±1.40) times, (2.86 0.56) times vs. (3.25±0.63) times], and the differences were statistically significant (t=2.945 and 3.584; both P<0.05). Conclusion　The personalized care plan based on the concept of precision medicine can reduce the medical fear and recurrence frequency of children with AD, improve treatment compliance and self-management ability, and result in higher satisfaction among family members. It has clinical promotion value.

Key words:

Autoimmune disease, Precision medicine, Personalized care, Therapy adherence, Satisfaction with care, Children

摘要：

目的　探讨基于精准医疗理念的儿童自身免疫性疾病（AD）个性化护理方案应用效果。方法　选取2022年3月至2024年3月于河南省人民医院就诊的120例AD患儿进行随机对照试验，采用随机数字表法分为研究组和对照组，各60例。对照组：男31例，女29例，年龄（9.04±1.39）岁，实施常规护理；研究组：男35例，女25例，年龄（9.36±1.87）岁，在对照组基础上实施基于精准医疗理念的个性化护理。两组均护理1个月，随访6个月。比较两组患儿护理前后的医疗恐惧程度、治疗依从性、自我管理能力，以及患儿家属护理满意度和出院后复发频次。统计学方法采用t检验、χ²检验。结果　护理后，研究组患儿医疗恐惧程度评分低于对照组［（4.67±0.81）分比（5.99±0.95）分］，差异有统计学意义（t=8.190，P<0.05）；研究组患儿治疗依从性、自我管理能力评分、家属护理满意度均高于对照组［（90.85±7.02）分比（87.59±5.92）分、（78.85±4.05）分比（76.74±4.16）分、91.67%（55/60）比71.67%（43/60）］，差异均有统计学意义（t=2.75、2.815，χ²=8.015，均P<0.05）；研究组患儿出院后3个月、6个月复发频次均低于对照组［（4.00±0.67）次比（4.59±1.40）次、（2.86±0.56）次比（3.25±0.63）次］，差异均有统计学意义（t=2.945、3.584，均P<0.05）。结论　基于精准医疗理念的个性化护理方案可降低AD患儿医疗恐惧程度和复发频次，提高治疗依从度、自我管理能力，家属满意度高，具有临床推广价值。

关键词:

自身免疫性疾病, 精准医疗, 个性化护理, 治疗依从性, 护理满意度, 儿童