Abstract:

Objective　To explore the effect of integrated moxibustion therapy with fire dragon pot on patients with cough and asthma of chronic obstructive pulmonary disease (COPD). Methods　This study was a randomized controlled trial. A total of 86 COPD patients with cough and asthma admitted to Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian) from October 2022 to October 2023 were selected as the study objects by the convenience sampling method. The patients were divided into a control group (43 cases) and a treatment group (43 cases) by the random number table method. In the treatment group, 3 patients were admitted to the intensive care unit due to aggravation of the disease and could not continue the study; in the control group, 2 patients could not continue the study because the patient left Shenzhen, and 1 patient failed to follow the doctor's advice to withdraw by themselves. Each 40 patients in the treatment group and control group completed the study. In the control group, there were 28 males and 12 females, aged 43-79 (60.12±5.23) years, and the course of disease ranged from 2 to 13 (10.09±2.23) years. In the treatment group, there were 30 males and 10 females, aged 41-78 (60.56±5.18) years, and the course of disease ranged from 2 to 14 (10.12±2.13) years. The control group was treated with routine nursing and rehabilitation training, and the treatment group was treated with integrated moxibustion therapy with fire dragon pot on the basis of the control group. Both groups were treated continuously for 30 days. The cough and asthma relief rate and pulmonary function indicators [forced vital capacity (FVC), forced expiratory volume in the first second (FEV₁), and FEV₁/FVC], morning symptoms [Chronic Obstructive Pulmonary Disease Morning Symptom Diary (CPLD-MSD)], respiratory function [St.George's Respiratory Questionnaire (SGRQ) and modified Medical Research Council (mMRC)], traditional Chinese medicine (TCM) syndrome score, blood gas analysis indexes [oxygen partial pressure (PaO₂) and carbon dioxide partial pressure (PaCO₂)] before and after treatment were compared between the two groups. Independent sample t test, paired t test, and χ² test were used for statistical analysis. Results　The total relief rate of cough and asthma in the treatment group was higher than that in the control group [95.00% (38/40) vs. 80.00% (32/40)] (P<0.05). After treatment, the FVC, FEV₁, and FEV₁/FVC in the treatment group were higher than those in the control group [(2.51±0.38) L vs. (2.17±0.35) L, (1.38±0.43) L vs. (1.13±0.37) L, (65.47±5.34)% vs. (62.11±5.17)%] (all P<0.05). The scores of COPD-MSD, SGRQ, and mMRC in the treatment group were lower than those in the control group [(51.78±3.21) points vs. (63.22±3.23) points, (48.19±6.23) points vs. (55.23±6.21) points, (1.48±0.51) points vs. (2.48±0.72) points] (all P<0.05). The main symptom score, secondary symptom score, and total score of TCM syndrome scale in the treatment group were lower than those in the control group [(5.58±1.42) points vs. (8.55±1.71) points, (3.11±0.31) points vs. (5.23±0.44) points, (8.12±0.55) points vs. (13.62±0.72) points] (all P<0.05). The PaO₂ of the treatment group was higher than that of the control group [(76.11±5.12) mmHg (1 mmHg = 0.133 kPa) vs. (65.15±5.11) mmHg], but the PaCO₂ was lower than that of the control group [(48.17±6.32) mmHg vs. (55.23±6.21) mmHg] (both P<0.05). Conclusion　The choice of integrated moxibustion therapy with fire dragon pot for patients with COPD cough and asthma can not only effectively relieve the patients' cough and asthma symptoms, but also enhance their lung function, improve their respiratory function and morning symptoms.

Key words:

Chronic obstructive pulmonary disease, Cough and asthma, Integrated moxibustion therapy with fire dragon pot, Lung function,  , Morning symptom

摘要：

目的　探讨火龙罐综合灸疗法对慢阻肺咳喘患者的影响。方法　本研究为随机对照试验。采用便利抽样法，选取2022年10月至2023年10月广州中医药大学深圳医院（福田）收治的86例慢阻肺咳喘患者作为研究对象。采用随机数字表法，将患者分为对照组（43例）与治疗组（43例）。治疗组因疾病加重入住重症加强护理病房无法继续研究脱落3例，对照组因患者离开深圳无法继续研究脱落2例，未能遵循医嘱自行退出1例，治疗组、对照组各40例完成本研究。对照组男28例，女12例；年龄43～79（60.12±5.23）岁；病程2～13（10.09±2.23）年。治疗组男30例，女10例；年龄41～78（60.56±5.18）岁。病程2～14（10.12±2.13）年。对照组采用常规治疗护理和康复训练，治疗组在对照组基础上采用火龙罐综合灸疗法。两组均连续治疗30 d。比较两组咳喘缓解情况，治疗前后肺功能指标［最大肺活量（FVC）、第1秒用力呼气容积（FEV₁）、FEV₁/FVC］、晨间症状［慢阻肺晨间症状量表（COPD-MSD）］、呼吸功能［圣乔治呼吸问卷（SGRQ）、改良呼吸困难指数（mMRC）］、中医证候评分、血气指标［氧分压（PaO₂）、二氧化碳分压（PaCO₂）］。采用独立样本t检验、配对t检验和χ²检验进行统计学分析。结果　治疗组咳喘总缓解率高于对照组［95.00%（38/40）比80.00%（32/40）］（P<0.05）。治疗后，治疗组FVC、FEV₁和FEV₁/FVC均高于对照组［（2.51±0.38）L比（2.17±0.35）L、（1.38±0.43）L比（1.13±0.37）L、（65.47±5.34）%比（62.11±5.17）%］（均P<0.05）；治疗组COPD-MSD、SGRQ和mMRC评分均低于对照组［（51.78±3.21）分比（63.22±3.23）分、（48.19±6.23）分比（55.23±6.21）分、（1.48±0.51）分比（2.48±0.72）分］（均P<0.05）；治疗组中医证候量表主症、次症评分和总分均低于对照组［（5.58±1.42）分比（8.55±1.71）分、（3.11±0.31）分比（5.23±0.44）分、（8.12±0.55）分比（13.62±0.72）分］（均P<0.05）；治疗组PaO₂高于对照组［（76.11±5.12）mmHg（1 mmHg=0.133 kPa）比（65.15±5.11）mmHg］，PaCO₂低于对照组［（48.17±6.32）mmHg比（55.23±6.21）mmHg］（均P<0.05）。结论　火龙罐综合灸疗法可有效缓解慢阻肺咳喘患者症状，改善肺功能、呼吸功能及晨间症状。

关键词:

慢阻肺, 咳喘, 火龙罐综合灸疗法, 肺功能, 晨间症状