XBP1、Twist1、VEGF在人脑胶质瘤中的表达及临床意义

doi:10.3760/cma.j.issn.1007-1245.2023.02.009

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (2): 183-.DOI: 10.3760/cma.j.issn.1007-1245.2023.02.009

XBP1、Twist1、VEGF在人脑胶质瘤中的表达及临床意义

周保丹高飞王淇民王明国

南阳市第二人民医院神经外科，南阳　473000

出版日期:2023-01-15 发布日期:2023-01-30
通讯作者: 周保丹，Email：zhoubd228@163.com
基金资助:
河南省医学科技攻关计划项目（LHGJ20191471）

Expressions and clinical significance of XBP1, Twist1, and VEGF protein in human glioma

Zhou Baodan, Gao Fei, Wang Qimin, Wang Mingguo

Department of Neurosurgery, The Second People's Hospital of Nanyang City, Nanyang 473000, China

Online:2023-01-15 Published:2023-01-30
Contact: Zhou Baodan, Email: zhoubd228@163.com
Supported by:
Project of Problem-tackling Plan of Medical Science and Technology in Henan (LHGJ20191471)

摘要/Abstract

摘要：

目的　探讨X盒结合蛋白1（XBP1）、Twist相关蛋白1（Twist1）、血管内皮生长因子（VEGF）在人脑胶质瘤中的表达及临床意义。方法　选取2018年9月至2020年6月南阳市第二人民医院保存的50份脑胶质瘤组织作为研究对象，其中男性28例，女性22例，年龄（37.66±5.66）岁，根据预后将其分为生存组和死亡组。同时选取40份正常脑组织作为对照组，男性24例，女性16例，年龄（37.75±7.68）岁。检测各组组织XBP1、Twist1、VEGF阳性表达；分析其与临床病理特征的相关性；采用logistic回归分析影响患者预后的危险因素；Kaplan-Meier进行生存分析。结果　与对照组相比，生存组和死亡组XBP1、Twist1、VEGF阳性表达均较高（χ²=57.270、55.350、55.589，均P<0.05）；XBP1、Twist1、VEGF与患者组织分化（χ²=6.349、10.938、8.140，P=0.012、0.001、0.004）、临床分期（χ²=4.504、8.295、6.062，P=0.034、0.004、0.014）以及Karnofsky功能状态评分（χ²=8.333、4.688、6.527，P=0.004、0.067、0.011）有显著相关性；XBP1、Twist1、VEGF均是影响患者预后的危险因素（均P<0.05）；与XBP1、Twist1、VEGF阴性表达相比，阳性表达患者的生存时间较短，均P<0.05。结论　XBP1、Twist1、VEGF与脑胶质瘤患者临床病理特征、预后及生存有一定的相关性。

关键词:

XBP1, Twist1, VEGF, 脑胶质瘤

Abstract:

Objective　To investigate the expression and clinical significance of X-box binding protein 1 (XBP1), Twist related protein 1 (Twist1), and vascular endothelial growth factor (VEGF) in human glioma. Methods　Fifty cases of glioma tissue preserved in The Second People's Hospital of Nanyang City from September 2018 to June 2020 were selected; of which, 28 cases were male and 22 cases were female, with an age of (37.66±5.66) years; they were divided into a survived group and a death group according to their prognosis. Forty cases of normal brain tissue were selected as a control group, including 24 males and 16 females who were (37.75±7.68) years old. The positive expressions of XBP1, Twist1, and VEGF in the tissues of both groups were detected. Their correlations with clinicopathological features were analyzed. The logistic regression analysis was used to analyze the risk factors affecting patient prognosis. Kaplan-Meier was used for survival analysis. Results　The positive expressions of XBP1, Twist1, and VEGF in the survived group and the death group were higher than those in the control group (χ²=57.270, 55.350, and 55.589; all P<0.05). XBP1, Twist1, and VEGF were associated with the patients' tissue differentiation (χ²=6.349, 10.938, and 8.140; P=0.012, 0.001, and 0.004), clinical stage (χ²=4.504, 8.295, and 6.062; P=0.034, 0.004, and 0.014), and Karnofsky Performance Status score (χ²=8.333, 4.688, and 6.527; P=0.004, 0.067, and 0.011); XBP1, Twist1, and VEGF were risk factors affecting the patients' prognosis (all P<0.05); the patients with positive expressions of XBP1, Twist1, and VEGF had shorter survival time than those with negative expressions (all P<0.05). Conclusion　XBP1, Twist1, and VEGF have certain correlations with clinicopathological features, prognosis, and survival of glioma patients.

Key words:

XBP1, Twist1, VEGF, Glioma

周保丹高飞王淇民王明国.

XBP1、Twist1、VEGF在人脑胶质瘤中的表达及临床意义 [J]. 国际医药卫生导报, 2023, 29(2): 183-.

Zhou Baodan, Gao Fei, Wang Qimin, Wang Mingguo.

Expressions and clinical significance of XBP1, Twist1, and VEGF protein in human glioma [J]. International Medicine and Health Guidance News, 2023, 29(2): 183-.

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XBP1、Twist1、VEGF在人脑胶质瘤中的表达及临床意义

Expressions and clinical significance of XBP1, Twist1, and VEGF protein in human glioma

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