TCF7L2及经典Wnt信号通路在肝癌中作用的研究进展

doi:10.3760/cma.j.issn.1007-1245.2023.02.001

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (2): 149-.DOI: 10.3760/cma.j.issn.1007-1245.2023.02.001

• 医学新进展 • 下一篇

TCF7L2及经典Wnt信号通路在肝癌中作用的研究进展

姚宝乐朱晓娟温望文戴伟刘圣兰黄浩

赣南医学院，赣州　341000

出版日期:2023-01-15 发布日期:2023-01-30
通讯作者: 黄浩，Email： hhuang@gmu.edu.cn
基金资助:
国家自然科学基金（82111530101、81803493）；江西省杰出青年基金项目（20212ACB216002）；江西省青年井冈学者奖励计划（QNJG2019089）

Roles of TCF7L2 and canonical Wnt signaling pathway in liver cancer

Yao Baole, Zhu Xiaojuan, Wen Wangwen, Dai Wei, Liu Shenglan, Huang Hao

Gannan Medical University, Ganzhou 341000, China

Online:2023-01-15 Published:2023-01-30
Contact: Huang Hao, Email: hhuang@gmu.edu.cn
Supported by:
National Natural Science Foundation (82111530101 and 81803493); Jiangxi Distinguished Young Scholar Fund Proejct (20212ACB216002); Jiangxi Province Young Jinggang Scholar Award Plan (QNJG2019089)

摘要/Abstract

摘要：

肝癌（liver cancer，LC）是最常见的致命恶性肿瘤，而早期不易被发现、难诊断，是其高致死率的主要原因。转录因子7样2（transcription factor 7 like 2，TCF7L2）是Wnt/β连环蛋白（β-catenin）信号通路的转录因子，β-catenin对TCF7L2的激活具有直接调控作用。在肝发育和肝再生阶段，激活Wnt/β-catenin信号通路可促进肝组织的生成。然而，在正常的成熟肝细胞中，β-catenin活性被抑制。肝损伤和肝癌激活β-catenin对TCF7L2的转录功能活化，诱导肝损伤因子和促肝癌因子的表达，且TCF7L2的表达与肝癌的发生和进展呈正相关。TCF7L2是一个潜在的肝癌诊断及治疗靶点。

关键词:

肝癌, Wnt/β-catenin, TCF7L2

Abstract:

Liver cancer (LC), the most common malignant tumor with a high mortality rate, has been a globally tricky health problem characterized by difficult detection and diagnosis. Transcription factor 7 like 2 (TCF7L2) is the transcription factor in the canonical Wnt/β-catenin singnaling pathway, and β-catenin directly activates TCF7L2. During liver development and regeneration, the activation of canonical Wnt/β-catenin induces the formation of liver tissue. However, in normal mature healthy hepatocytes, β-catenin is inhibited. Liver damage and LC initiate the event that TCF7L2 transcriptionally activites downstream damaged targets in the β-catenin-dependent manner. The expression of TCF7L2 is positively correlated with the occurrence and progression of hepatocellular carcinoma. TCF7L2 is a potential target for the diagnosis and treatment of liver cancer.

Key words:

Liver cancer, Wnt/β-catenin, TCF7L2

姚宝乐朱晓娟温望文戴伟刘圣兰黄浩.

TCF7L2及经典Wnt信号通路在肝癌中作用的研究进展 [J]. 国际医药卫生导报, 2023, 29(2): 149-.

Yao Baole, Zhu Xiaojuan, Wen Wangwen, Dai Wei, Liu Shenglan, Huang Hao.

Roles of TCF7L2 and canonical Wnt signaling pathway in liver cancer [J]. International Medicine and Health Guidance News, 2023, 29(2): 149-.

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TCF7L2及经典Wnt信号通路在肝癌中作用的研究进展

Roles of TCF7L2 and canonical Wnt signaling pathway in liver cancer

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