关键词: 不寐, 柴胡桂枝干姜汤加味, 肝郁痰凝

Abstract: Objective　To evaluate the effectiveness and safety of modified Chaihu Guizhi Ganjiang decoction for insomnia (stagnation of liver-qi and phlegm). Methods　Sixty cases of insomnia patients diagnosed as stagnation of liver-qi and phlegm treated at Department of Traditional Chinese Medicine, Jieyang People's Hospital from August 2021 to June 2022 were selected, and were divided into an observation group and a control group by the random number table method, with 30 cases in each group. There were 10 males and 20 females in the observation group, and they were (50.40±16.30) year old. There were 8 males and 22 females in the control group, and they were (50.17±14.80) year old. The observation group were treated with modified Chaihu Guizhi Ganjiang decoction, and the control group with hypnotics (zolpidem tartrate), for 2 weeks. The scores of Athens Insomnia Scale (AIS) and traditional Chinese medicine (TCM) syndromes, effectiveness, and safety in the two groups were observed and compared. t and χ² tests were applied. Results　The AIS scores before and after the treatment were (11.77±1.83) and (6.63±1.30) in the control group, and were (10.90±1.88) and (4.80±1.50) in the observation group; the AIS scores of the two groups after the treatment were significantly lower than those before the treatment, with statistical differences (both P<0.05); the AIS score of the observation group after the treatment was much better than that of the control group, with a statistical difference (P<0.05). The TCM syndrome scores before and after the treatment were (9.50±1.61) and (9.27±2.32) in the control group, and were (9.60±1.81) and (4.17±1.86) in observation group; the TCM syndrome score of the observation group after the treatment was significantly lower than that before the treatment, with a statistical difference (P<0.05). The effective rate was 73.33% (22/30) in the control group, and was 93.33% (28/30) in the observation group, with a statistical difference (P<0.05). The incidence of adverse reactions was 33.33% (10/30) in the control group, and was 10.00% (3/30) in the observation group, with a statistical difference (P<0.05). Conclusion　The modified Chaihu Guizhi Ganjiang decoction has definite curative effect on insomnia (stagnation of liver-qi and phlegm) and fewer adverse reactions, and can improve the patients' sleep quality and symptoms.

Key words: Insomnia, Modified Chaihu Guizhi Ganjiang decoction, Stagnation of liver-qi and phlegm