神经鞘脂代谢与铁死亡在肝癌中的研究进展

doi:10.3760/cma.j.issn.1007-1245.2022.21.009

国际医药卫生导报 ›› 2022, Vol. 28 ›› Issue (21): 3004-3008.DOI: 10.3760/cma.j.issn.1007-1245.2022.21.009

神经鞘脂代谢与铁死亡在肝癌中的研究进展

王俊楠^1,4 金俊飞^1,2,3,4

¹桂林医学院附属医院广西肝脏损伤与修复分子医学重点实验室，桂林　541001；²桂林医学院附属医院广西神经鞘脂代谢相关疾病基础研究重点实验室，桂林　541001；³桂林医学院中美健康与疾病脂质研究中心，桂林　541001；⁴桂林医学院附属医院肝胆胰外科实验室，桂林　541001

收稿日期:2022-08-06 出版日期:2022-11-01 发布日期:2022-11-16
通讯作者: 金俊飞，Email：changliangzijin@163.com
基金资助:
国家自然科学基金项目（81960520）；广西自然科学基金重点项目（2020GXNSFDA238006）；广西科技厅中央引导地方科技发展资金项目（ZY21195024）；“广西特聘专家”专项经费资助项目（2019B12）；广西医学高层次骨干人才“139”计划资助项目（G202002005）；广西壮族自治区卫生健康委员会广西神经鞘脂代谢相关疾病基础研究重点实验室建设经费（ZJC2020005）；广西医疗卫生重点学科建设经费（2021-8-4-3）；桂林市科学研究与技术开发计划项目（20210102-1）

Research progress of sphingolipid metabolism and ferroptosis in liver cancer

Wang Junnan^1,4, Jin Junfei^1,2,3,4

¹Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Affiliated Hospital of Guilin Medical University, Guilin 541001, China; ²Guangxi Health Commission Key Laboratory of Basic Research in Sphingolipid Metabolism Related Diseases, Affiliated Hospital of Guilin Medical University, Guilin 541001, China; ³China-USA Lipids in Health and Disease Research Center, Guilin Medical University, Guilin 541001, China; ⁴Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, China

Received:2022-08-06 Online:2022-11-01 Published:2022-11-16
Contact: Jin Junfei, Email: changliangzijin@163.com
Supported by:
Project of National Natural Science Foundation (81960520); Key Project of Natural Science Foundation of Guangxi (2020GXNSFDA238006); Project Supported by Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department (ZY21195024); Project Supported by Guangxi Distinguished Expert Special Fund (2019B12); Project Supported by "139" Medical High Level Talents Training Plan in Guangxi (G202002005); Construction Fund of Guangxi Health Commission's Key Laboratory of Basic Research in Sphingolipid Metabolism Related Diseases (ZJC2020005); Construction Fund of Key Disciplines of Medical and Health in Guangxi (2021-8-4-3); Science and Technology Planned Project in Guilin (20210102-1)

摘要/Abstract

摘要： 铁死亡（ferroptosis）是不同于凋亡的一种细胞死亡方式，最新研究发现在肝癌治疗以及肝癌耐药等过程铁死亡参与其中。大量研究证实神经鞘脂代谢和肝癌发生、发展密切相关。神经鞘脂代谢通路和铁死亡通路存在交互作用，两者都与肝癌密切相关。本文就神经鞘脂代谢通路与铁死亡通路的交互作用以及对肝癌发生、发展、治疗等方面影响的近期研究进展进行阐述。

关键词: 铁死亡, 鞘脂代谢, 肝癌

Abstract: Ferroptosis is a cell death mode different from apoptosis. Recent studies have found that ferroptosis involves in the treatment and drug resistance of liver cancer. A large number of studies have confirmed that sphingolipid metabolism is closely related to the occurrence and development of liver cancer. There is interaction between sphingolipid metabolism pathway and ferroptosis pathway, and both are closely related to liver cancer. This article reviews the recent research progress on the interaction between sphingolipid metabolism pathway and ferroptosis pathway and its influence on the occurrence, development, and treatment of liver cancer.

Key words: Ferroptosis, Sphingolipid metabolism, Liver cancer

王俊楠金俊飞. 神经鞘脂代谢与铁死亡在肝癌中的研究进展[J]. 国际医药卫生导报, 2022, 28(21): 3004-3008.

Wang Junnan, Jin Junfei. Research progress of sphingolipid metabolism and ferroptosis in liver cancer [J]. International Medicine and Health Guidance News, 2022, 28(21): 3004-3008.

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神经鞘脂代谢与铁死亡在肝癌中的研究进展

Research progress of sphingolipid metabolism and ferroptosis in liver cancer

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