高分子聚合物用于siRNA递送系统的研究进展

doi:10.3760/cma.j.issn.1007-1245.2022.16.035

摘要/Abstract

摘要： 小干扰RNA（siRNA）具有沉默互补的目标信使RNA（mRNA）从而抑制疾病相关基因表达的作用。因其高效性及特异性，siRNA具有作为基因药物的巨大潜力，但其在体内易受到血管屏障、内涵体及RNA酶等因素的影响，从而难以发挥药效。因此，设计高效的能够负载siRNA的纳米载体以使其富集至靶标是目前siRNA药物研发的重要任务，高分子聚合物纳米载体是目前研究热点之一。本文就高分子聚合物纳米载体实现siRNA药物递送的研究进展进行综述。

关键词: 小干扰RNA, 高分子聚合物, 纳米载体, 药物递送

Abstract: Small interfering RNA (siRNA) has the effect of silencing target messenger RNA (mRNA) to inhibit the expressions of disease-related genes. Because of its high efficiency and specificity, siRNA has great potential as a gene drug, but it is easily inactivated by factors such as vascular barrier, endosomal escape, and RNase in vivo. Therefore, it is important to design efficient siRNA-loaded nanocarriers to deliver them to the target for the research of siRNA drug, while polymer nanocarriers are one of the current research hotspots. In this study, the research progress of polymer nanocarriers for siRNA drug delivery is reviewed.

Key words: siRNA, Polymer, Nanocarriers, Drug delivery

王富喜邓宏图王滨. 高分子聚合物用于siRNA递送系统的研究进展[J]. 国际医药卫生导报, 2022, 28(16): 2366-2369.

Wang Fuxi, Deng Hongtu, Wang Bin. Research progress of polymer used in siRNA delivery system[J]. International Medicine and Health Guidance News, 2022, 28(16): 2366-2369.

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