国际医药卫生导报 ›› 2022, Vol. 28 ›› Issue (11): 1595-1597.DOI: 10.3760/cma.j.issn.1007-1245.2022.11.027

• 病例报告 • 上一篇    下一篇

哌拉西林钠他唑巴坦钠致多发伤患者发热并急性肝损伤1例

李瑞1  王瑞洁2  孙斌1  张洪光1  袁莹1  邱建清1   

  1. 1滨州医学院附属医院急诊科,滨州 256600; 2滨州市中医医院内科,滨州 256600
  • 收稿日期:2022-02-09 出版日期:2022-06-01 发布日期:2022-06-15
  • 通讯作者: 邱建清,Email:qjq6341@163.com

One case of multiple injuries with fever and acute liver injury caused by piperacillin sodium and tazobactam sodium

Li Rui1, Wang Ruijie2, Sun Bin1, Zhang Hongguang1, Yuan Ying1, Qiu Jianqing1   

  1. 1 Emergency Department, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China;  2 Department of Internal Medicine, Binzhou Hospital of Traditional Chinese Medicine, Binzhou 256600, China
  • Received:2022-02-09 Online:2022-06-01 Published:2022-06-15
  • Contact: Qiu Jianqing, Email: qjq6341@163.com

摘要: 哌拉西林是一种广谱青霉素类抗生素,当与β-内酰胺酶抑制剂他唑巴坦联用时用于治疗敏感菌所致的中度至重度感染性疾病,常见的不良反应有过敏、皮疹、胃肠道反应等,亦可致发热并药物性肝损伤,但导致发热并急性肝损伤的病例罕见。本文报道1例患者应用哌拉西林钠他唑巴坦钠时出现的发热并急性肝损伤的病例,目的是能引起临床医生的关注,并为早发现、早诊断、早干预提供参考。

关键词: 哌拉西林钠他唑巴坦钠, 药物性肝损伤, 药品不良反应

Abstract: Piperacillin is a broad-spectrum penicillin antibiotic. It is used in combination with β-lactamase inhibitor tazobactam for moderate to severe infectious diseases caused by sensitive bacteria. Its common adverse reactions include allergy, rash, gastrointestinal reactions, etc., and can also lead to fever and drug-induced liver injury, but cases resulted in fever and acute liver injury are rare. This paper reports the fever and acute liver injury in a patient who was treated with piperacillin sodium and tazobactam sodium. The purpose is to arouse the attention of clinicians, and to provide references for early detection, diagnosis, and intervention.

Key words: Piperacillin sodium and tazobactam sodium, Drug-induced liver injury, Adverse drug reactions