关键词:

1型糖尿病, 脂肪增生, 黄芪酊, 血糖, 按摩

Abstract:

Objective　To explore the efficacy of Astragalus Tincture combined with massage on lipohypertrophy (LH) and blood glucose in patients with type 1 diabetes (T1DM). Methods　A prospective study was conducted to select T1 DM patients aged 3-16 years with LH at the insulin injection site who were followed up in the endocrinology clinic of Quanzhou Maternal and Child Health Hospital from May 2023 to March 2024. The patients were divided into control group and experimental group by random number method, with 30 cases in each group. A total of 5 cases were lost during the intervention, including 3 cases in the experimental group and 2 cases in the control group. All of them failed to be followed up in time after the intervention, and the improvement of LH could not be judged. In the control group, there were 15 males and 13 females, aged (10.50±2.59) years, and the course of disease was (34.14±19.42) months. There were 13 males and 14 females in the experimental group, aged (9.74±3.65) years old, and the course of disease was (32.67±18.98) months. The control group was treated with 25% magnesium sulfate hot and humid compress, and the experimental group was treated with Huangqi tincture rubbing + massage, 2 times/d, for 14 days.The improvement of LH, blood glucose compliance rate at different time periods [before three meals, 2 h after meals, before bedtime (22:00), early morning (03:00)] and the incidence of hypoglycemia were compared between the two groups after intervention. The statistical methods were t test, χ² test and rank sum test. Results　After the intervention, 23 cases (85.19%) in the experimental group and 16 cases (57.14%) in the control group showed effective improvement in LH, with statistical differences (χ²=5.240, P=0.022). There were statistically significant differences in blood glucose daily compliance between the two groups at different time periods after intervention (all P<0.05). There were 11 cases of hypoglycemia in the two groups, including 2 cases (7.41% ) in the experimental group and 9 cases (32.14%) in the control group, with statistical differences (χ²=4.313, P=0.038). Conclusions　Astragalus tincture combined with massage can effectively improve LH levels in patients with T1DM, which is beneficial for controlling their blood sugar and reducing the occurrence of hypoglycemic events.

Key words:

Type 1 diabetes, Lipohypertrophy, Astragalus tincture, Blood glucose, Massage