关键词:

苯磺酸氨氯地平, 牙龈增生, 儿童, Alport综合征

Abstract:

This article analyzed a boy with Alport syndrome who has been taking amlodipine besylate for a long time . The 15-year-old boy was diagnosed with Alport syndrome at 7 years and 7 months old (May 2016), and progressed to chronic kidney disease stage 5 at 10 years and 4 months old (February 2019). He started peritoneal dialysis in March 2019, and had been taking various antihypertensive drugs for many years due to the existence of malignant hypertension. However, his blood pressure was not well controlled, mostly in the 130-150/90-110 mmHg (1 mmHg= 0.133 kPa) range. Gingival hyperplasia occurred in February 2023 and gradually worsened. CT examination, bone marrow cell blood examination, physical examination, and medication history were performed to diagnose the gingival hyperplasia associated with calcium channel blockers (CCB). Gingival hyperplasia improved significantly after amlodipine reduction. The exact mechanism of drug-induced gingival hyperplasia is not fully understood. Whether the severe gingival hyperplasia manifestation is related to the gene mutation causing collagen synthesis abnormality or increased drug susceptibility in the patient's underlying disease of Alport syndrome needs further research.

Key words:

Amlodipine besylate, Gingival hyperplasia, Children, Alport syndrome