关键词: 念珠菌, 药敏试验, Rosco纸片扩散法

Abstract: Objective　To monitor the isolates of genital Candidiasis in Guangzhou from 2013 to 2019, and to evaluate the susceptibilities of 7 antibioitics. Methods　Six hundred and forty-nine patients with genital Candidiasis infection treated at Clinic of Sexually Transmitted Diseases, Guangzhou Institute of Dermatology from January 2013 to December 2019 were selected, including 116 males and 533 females, and they were 15-84 years old. The ATB ID32C bioMerieux France and Rosco Disk diffusion method was be used to do the typing and drug sensitivity test of Candidiasis. The susceptibilities for all kinds of Candidasis were compared. Results　Among the 649 strains of genital Candidiasis, there were 517 strains of candida albicans (79.66%), 72 strains of candida glabrata (11.09%), 33 strains of candida parapsilosis (5.09%), and 27 strains of other Candidiasis (4.16%). The isolatation rate of candida albicans during these 7 years did not changed obviously (χ²=11.56, P>0.05), that of  candida glabrata increased (χ²=13.72, P<0.05), and those of candida parapsilosis and other candida decreased (χ²=19.28 and 14.76,both P<0.05). The susceptibilities of genital candida to nystatin, ketoconazole, fluconazole, itraconazole, miconazole, and terbinafine were 99.69% (647/649), 85.20% (553/649), 72.57% (471/649), 52.23% (339/649), 34.36% (223/649), 34.98% (227/649), and 8.32% (54/649). Conclusions　The genital Candidiasis is candida albicans. Candidiasis has a high drug-susceptibility rate to polyene antibiotics, and is resistant against azoles. Different kinds of Candidiasis have different antibiotic sensitivities.

Key words: Candidiasis, Drug susceptibility test, Rosco disk diffusion method