关键词: 反流性食管炎, 幽门螺杆菌, 感染, 相关性

Abstract: Objective To explore the relationship between reflux esophagitis (RE) and Helicobacter pylori (Hp) infection. Methods Two hundred and twenty-five patients with RE treated at Xinjiang Uyghur Medical Hospital from March 2019 to April 2024 were selected as the research objects. They were years (47.0±13.1) old. According to the endoscopic results, they wereclassified into four levels based on the Los Angeles (LA) classification criteria: A, B, C, and D. The patients of grades A and B were included into a mild group, while the patients of grades C and D a severe group. The Hp infection was determined by the C14 breath test. The infection status of Hp in the patients with different grades of RE and in the patients of different ages was compared. The factors influencing Hp infection in the patients were analyzed by the multivariate logistic regression. χ2 test was used for the statistical analysis. Results Among the 225 patients, there were 104 males (46.2%), 121 females (53.8%), and 115 cases (51.1%) of Hp infection. The Hp infection rate in the mild group was higher than that in the severe group [54.9% (113/206) vs. 10.5% (2/19)]; the Hp infection rate in the Uyghur patients was higher than that in other ethnic groups [53.5% (106/198) vs. 33.3% (9/27)]; there were statistical differences (χ2 =13.679 and 3.381; both P<0.05). There was no statistical difference in the Hp infection rate between the males and the females (P>0.05). The detection rate of Hp increased with age; the Hp infection rates in the patients who were 60-<70 and 70-80 years old were higher than that in the patients who were 18-<30 years old, with statistical differences (χ2 =5.128 and 4.212; both P<0.05). The Hp infection rates in the patients of grades A, B, C, and D were 52.3% (79/151), 61.8% (34/55), 11.8% (2/17), and 0 (0/2), respectively, with a statistical difference (χ2 =15.235; P< 0.01). The Hp infection rate decreased as the endoscopic grading increased. Pharyngitis was a risk factor for Hp infection in the patients. Conclusions The severity of RE is inversely proportional to the infection rate of Hp; Hp plays a protective role in the occurrence and development of RE to a certain extent; the treatment process should strictly follow the eradication indications of Hp and select appropriate timing for clearance.

Key words: Reflux esophagitis, Helicobacter pylori, Infection, Correlation