关键词:

子宫内膜癌, 血脂异常, p53突变型, 恶性程度

Abstract:

Objective　To explore the incidence of dyslipidemia in patients with endometrial cancer and the correlation between dyslipidemia and the risk of p53 mutant endometrial cancer. Methods　A total of 136 patients who underwent no preoperative treatment and were pathologically diagnosed with endometrial cancer after surgery at Binzhou Medical University Hospital from November 2019 to April 2024 were selected, including 64 cases of wild-type p53 and 72 cases of p53 mutation. The blood lipid levels were collected during their first fasting period at admission for the univariate analysis. The statistically significant factors were included in the multivariate logistic regression analysis. The receiver operating characteristic curve (ROC) was drawn. The patients' postoperative pathological parameters, depth of myometrial infiltration, staging, degree of tissue differentiation, and lymph node metastasis, were collected; their relationship with p53 mutant endometrial cancer was analyzed. t test, Mann-Whitney U test and χ² test were used for statistical comparison. Results　The level of TC, TG, LDL, and HDL in the p53 mutant endometrial cancer group were higher than those in the p53 wild-type endometrial cancer group, with statistical differences (all P<0.001). The inclusion of binary logistic regression analysis resulted in TC (OR=0.959, 95%CI 0.253-3.757, P=0.952), TG (OR=1.398, 95%CI 0.703-2.965, P=0.357), LDL (OR=8.205, 95%CI 1.472-50.567, P=0.019), and HDL (OR=2.252, 95%CI 0.373-14.255, P=0.378). The ROC analysis showed that the sensitivity of LDL in predicting the occurrence of p53 mutant endometrial cancer was 0.828; the specificity was 0.792; the optimal cutoff value was 2.41; the area under the curve (AUC) was 0.843. There were statistical differences in staging, tissue differentiation, and lymph node metastasis (all P<0.05) but no statistical difference in the depth of muscle infiltration (P>0.05) between wild-type and mutant p53 endometrial cancer. Conclusions　LDL is a risk factor for developing p53 mutant endometrial cancer, with high predictive value. Moreover, the prognosis of patients with p53 mutant endometrial cancer is poor. LDL is expected to become an indicator for predicting the classification and malignancy of endometrial cancer.

Key words:

Endometrial cancer, Dyslipidemia, p53 mutant type, Malignant degree