寻常型银屑病患者Th1、Th17和miR-150表达与病情进展的关系

doi:10.3760/cma.j.issn.1007-1245.2024.16.022

国际医药卫生导报 ›› 2024, Vol. 30 ›› Issue (16): 2743-2746.DOI: 10.3760/cma.j.issn.1007-1245.2024.16.022

寻常型银屑病患者Th1、Th17和miR-150表达与病情进展的关系

吕明军姚佳雯宋颖

宝鸡市人民医院皮肤科，宝鸡　721000

收稿日期:2023-12-27 出版日期:2024-08-15 发布日期:2024-09-04
通讯作者: 姚佳雯，Email：273025953@qq.com
基金资助:
陕西省科技计划发展项目-重点产业创新链（2021ZDLSF04-12）

Relationships between Th1, Th17, and miR-150 expressions and disease progression in patients with psoriasis vulgaris

Lyu Mingjun, Yao Jiawen, Song Ying

Department of Dermatology, Baoji People's Hospital, Baoji 721000, China

Received:2023-12-27 Online:2024-08-15 Published:2024-09-04
Contact: Yao Jiawen, Email: 273025953@qq.com
Supported by:
Shaanxi Province Science and Technology Plan Development Project - Key Industrial Innovation Chain (2021ZDLSF04-12)

摘要/Abstract

摘要：

目的　探讨寻常型银屑病（PV）患者外周血辅助性T细胞（Th）1、Th17和miR-150表达水平与病情进展程度的关系。方法　选取2021年2月至2023年4月宝鸡市人民医院收治的112例PV患者为PV组，并选取同期60名体检健康者为正常组。PV组男63例、女49例，年龄（46.89±12.35）岁；正常组男32例、女28例，年龄（44.36±11.22）岁。根据银屑病皮损面积和严重程度指数（PASI）将PV组分为轻度组、中度组和重度组。比较PV组和正常组Th1、Th17及miR-150水平，轻度组、中度组和重度组Th1、Th17、miR-150及相关细胞因子［白细胞介素（IL）-2、IL-17、IL-22］水平，分析Th1、Th17、miR-150表达水平与PASI评分的相关性。统计学方法采用t检验、F检验、χ²检验、Pearson相关性分析。结果　PV组Th1和Th17水平均高于正常组［（22.76±3.21）%比（16.83±1.65）%、（3.35±0.68）%比（1.25±0.37）%］，miR-150水平低于正常组［（0.80±0.09）比（0.99±0.15）］，差异均有统计学意义（t=13.38、22.21、10.38，均P<0.05）；轻度组Th1和Th17水平均低于中度组、高度组，miR-150水平高于中度组、高度组，差异均有统计学意义（F=85.29、19.41、92.93，均P<0.05）；轻度组IL-2、IL-17和IL-22水平均低于中度组、高度组，差异均有统计学意义（F=66.03、42.79、23.34，均P<0.05）；Pearson相关性分析显示，PV患者外周血Th1、Th17水平与PASI评分呈正相关（r=0.771、0.514，均P<0.05），miR-150水平与PASI评分呈负相关（r=-0.703，P<0.05）。结论　PV患者外周血Th1、Th17水平升高，miR-150水平下降，三者与PV病情进展严重程度相关。

关键词:

寻常型银屑病, 辅助性T细胞1, 辅助性T细胞17, miR-150, 病情程度

Abstract:

Objective　To investigate the relationships between the expression levels of peripheral blood T helper cell (Th)1, Th17, and miR-150 and the progression of psoriasis vulgaris (PV). Methods　A total of 112 PV patients admitted to Baoji People's Hospital from February 2021 to April 2023 were selected as a PV group, and 60 healthy individuals during the same period were selected as a control group. There were 63 males and 49 females in the PV group, aged (46.89±12.35) years. In the normal group, there were 32 males and 28 females, aged (44.36±11.22) years. According to the Psoriasis Area and Severity Index (PASI), the PV group was divided into mild, moderate, and severe groups. The levels of Th1, Th17, and miR-150 in the PV group and the control group were compared, and the levels of Th1, Th17, miR-150, and related cytokines [interleukin (IL)-2, IL-17, and IL-22] in the mild, moderate, and severe groups were compared. The correlations between the expression levels of Th1, Th17, and miR-150 and PASI score were analyzed. The statistical methods used were t test, F test, χ² test, and Pearson correlation analysis. Results　The levels of Th1 and Th17 in the PV group were higher than those in the control group [(22.76±3.21)% vs. (16.83±1.65)%, (3.35±0.68)% vs. (1.25±0.37)%], and the level of miR-150 was lower than that in the control group [(0.80±0.09) vs. (0.99±0.15)], with statistically significant differences (t=13.38, 22.21, and 10.38, all P<0.05). The levels of Th1 and Th17 in the mild group were lower than those in the moderate and severe groups, and the level of miR-150 was higher than those in the moderate and severe groups, with statistically significant differences (F=85.29, 19.41, and 92.93, all P<0.05). The levels of IL-2, IL-17, and IL-22 in the mild group were lower than those in the moderate and severe groups, with statistically significant differences (F=66.03, 42.79, and 23.34, all P<0.05). Pearson correlation analysis showed that the levels of Th1 and Th17 in the peripheral blood of PV patients were positively correlated with PASI score (r=0.771 and 0.514, both P<0.05), and the level of miR-150 was negatively correlated with PASI score (r=-0.703, P<0.05). Conclusion　Increased levels of Th1 and Th17 and decreased miR-150 level in the peripheral blood of PV patients are associated with the severity of PV progression.

Key words:

Psoriasis vulgaris, , T-helper cell 1, , T-helper cell 17, , miR-150, , Severity

吕明军姚佳雯宋颖.

寻常型银屑病患者Th1、Th17和miR-150表达与病情进展的关系 [J]. 国际医药卫生导报, 2024, 30(16): 2743-2746.

Lyu Mingjun, Yao Jiawen, Song Ying.

Relationships between Th1, Th17, and miR-150 expressions and disease progression in patients with psoriasis vulgaris [J]. International Medicine and Health Guidance News, 2024, 30(16): 2743-2746.

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寻常型银屑病患者Th1、Th17和miR-150表达与病情进展的关系

Relationships between Th1, Th17, and miR-150 expressions and disease progression in patients with psoriasis vulgaris

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