关键词:

胎膜早破, 腔内感染, GATA结合蛋白-3, 巨噬细胞炎性蛋白-3α, 诊断价值

Abstract:

Objective　To investigate the value of serum GATA binding protein-3 (GATA-3) and macrophage inflammatory protein-3α (MIP-3α) levels in the diagnosis of intra-amniotic infection in patients with premature rupture of membranes. Methods　The clinical data of 123 patients with premature rupture of membranes treated in Weinan Central Hospital from October 2021 to August 2023 were retrospectively collected. The fifty-three patients who developed intra-amniotic infection were set as an infection group, while the 70 patients without infection were set as a non-infection group. The infection group were (27.65±3.58) years old and (36.47±3.04) weeks pregnant. The non-infection group were (27.71±3.69) years old and (37.52±3.27) weeks pregnant. The prenatal serum levels of GATA-3 and mip-3α in both groups were compared. t and χ² tests and receiver operating characteristic curve (ROC) were used to assess the value of GATA-3 and MIP-3α in the diagnosis of amniotic cavity infection in patients with premature rupture of membranes. Multivariate logistic regression analysis was conducted to identify the risk factors of amniotic cavity infections in the patients with premature rupture of membranes. Results　The levels of GATA-3 and MIP-3α in the infection group were (261.35±27.87) ng/L and (38.84±6.33) μg/L, and those in the non-infection group were (292.87±29.53) ng/L and (29.61±5.62) μg/L, with statistical differences (t=6.005 and 8.540; both P<0.05). The areas under the curves (AUC) of GATA-3 and MIP-3α for predicting intra-amniotic infection in the patients with PPROM were 0.789 and 0.855, respectively; the cutoff values were 276.74 ng/L and 36.04 μg/L; the specificities were 77.4% and 88.6%; the sensitivities were 75.7% and 71.7%. The combined detection of both had an AUC of 0.924, with a specificity of 94.3% and a sensitivity of 81.1%. GATA-3 ≤276.74 ng/L, MIP-3α ≥36.04 μg/L, history of miscarriage and induced abortion, and premature rupture of membranes were independent risk factors for intra-amniotic infection in the patients with premature rupture of membranes (all P<0.05). Conclusion　Abnormal serum levels of GATA-3 and MIP-3α in patients with premature rupture of membranes are risk factors for intra-amniotic infection, and have high diagnostic value for this condition.

Key words:

Premature rupture of membranes, Intra-amniotic infection, GATA binding protein-3, Macrophage inflammatory protein-3α, Diagnostic value