金天格胶囊和阿法骨化醇于老年OVCF患者PKP术后应用的效果

doi:10.3760/cma.j.issn.1007-1245.2024.09.018

国际医药卫生导报 ›› 2024, Vol. 30 ›› Issue (9): 1490-1494.DOI: 10.3760/cma.j.issn.1007-1245.2024.09.018

金天格胶囊和阿法骨化醇于老年OVCF患者PKP术后应用的效果

刘日富¹ 邹奇² 冯晓冰¹ 刘文成¹ 杨广华¹ 杨悦¹ 黄相杰¹ 王雪山³

¹山东文登整骨烟台医院骨关节一科，烟台　264000；²山东文登整骨烟台医院脊柱脊髓二科，烟台　264000；³山东文登整骨烟台医院影像科，烟台　264000

收稿日期:2023-09-23 出版日期:2024-05-01 发布日期:2024-05-30
通讯作者: 王雪山，Email：50699569@qq.com
基金资助:
山东省医药卫生科技发展计划（2019WS0553）

Effect of Jintiange capsules and alfacalcitol for elderly patients with OVCF after PKP

Liu Rifu¹, Zou Qi², Feng Xiaobing¹, Liu Wencheng¹, Yang Guanghua¹, Yang Yue¹, Huang Xiangjie¹, Wang Xueshan³

¹First Department of Osteoarthrosis, Shandong Wendeng Osteopaths Yantai Hospital, Yantai 264000, China; ²Second Department of Spinal Cord, Shandong Wendeng Osteopaths Yantai Hospital, Yantai 264000, China; ³Department of Imaging, Shandong Wendeng Osteopaths Yantai Hospital, Yantai 264000, China

Received:2023-09-23 Online:2024-05-01 Published:2024-05-30
Contact: Wang Xueshan, Email: 50699569@qq.com
Supported by:
Development Plan of Medical and Health Science and Technology in Shandong (2019WS0553)

摘要/Abstract

摘要：

目的　探讨金天格胶囊联合阿法骨化醇于老年骨质疏松性脊柱压缩性骨折（osteoporotic vertebral compression fracture，OVCF）患者经皮椎体后凸成形术（percutaneous kyphoplasty of vertebral body，PKP）术后应用的效果。方法　选取山东文登整骨烟台医院2020年2月至2023年5月收治的98例老年OVCF患者进行随机对照试验，采用掷硬币法将其分为对照组和观察组，各49例。对照组男26例，女23例，年龄（72.63±2.54）岁，病程（5.56±1.31）年。观察组男29例，女20例，年龄（72.89±2.60）岁，病程（5.37±1.23）年。两组患者给予PKP，对照组术后采用阿法骨化醇治疗，观察组术后另加用金天格胶囊治疗，两组均治疗3个月。治疗后，对比两组治疗效果、中医症候积分、疼痛程度、骨代谢指标、不良反应。采用χ²检验和t检验。结果　观察组治疗有效率高于对照组［97.96%（48/49）比81.63%（40/49）；χ²=7.127，P=0.008］。治疗3个月后，观察组主症积分、次症积分、疼痛程度评分均低于对照组［（3.20±0.28）分比（4.58±0.30）分、（1.20±0.16）分比（1.96±0.21）分、（1.58±0.27）分比（3.29±0.41）分；t=23.540、20.151、24.383，均P<0.001］。治疗3个月后，观察组骨钙素（osteocalcin，BGP）、骨碱性磷酸酶（bone alkaline phosphatase，BALP）水平均高于对照组［（10.26±1.57）μg/L比（8.26±1.02）μg/L、（18.26±1.63）μg/L比（16.84±1.29）μg/L；t=7.478、4.782，均P<0.001］。观察组不良反应发生率低于对照组［6.12%（3/49）比10.20%（5/49）］，但差异无统计学意义（χ²=0.136，P=0.712）。结论　老年OVCF患者PKP术后采用金天格胶囊联合阿法骨化醇治疗可明显改善临床症状，减轻疼痛程度，降低中医症候积分，改善骨代谢，安全性较好，值得推广。

关键词:

骨质疏松性脊柱压缩性骨折, 金天格胶囊, 阿法骨化醇, 经皮椎体后凸成形术

Abstract:

Objective　To investigate the effect of Jintiange capsules combined with alfacalcitol for elderly patients with osteoporotic vertebral compression fracture (OVCF) after percutaneous kyphoplasty of vertebral body (PKP). Methods　Ninety-eight elderly patients with OVCF treated at Shandong Wendeng Osteopaths Yantai Hospital from February 2020 to May 2023 were selected for the randomized controlled trial, and were divided into a control group and an observation group by the coin toss method, with 49 cases in each group. The control group included 26 males and 23 females, with an age of (72.63±2.54) years; their disease course was (5.56±1.31) years. In the observation group, there were 29 males and 20 females; they were (72.89±2.60) years old; their disease course was (5.37±1.23) years. The patients in both groups took PKP; after PKP, the control group took alfacalcitol, and the observation group took alfacalcitol and Jintiange capsules, for 3 months. After the treatment, the treatment effects, symptom scores of traditional Chinese medicine, pain degrees, bone metabolism indicators, and adverse reactions were compared between the two groups. χ² and t tests were applied. Results　The effective rate of the observation group was higher than that of the control group [97.96% (48/49) vs. (81.63% (40/49); χ²=7.127; P=0.008]. After 3 months' treatment, the scores of main symptoms, secondary symptoms, and pain degree in the in the observation group were lower than those in the control group [(3.20±0.28) vs. (4.58±0.30), (1.20±0.16) vs. (1.96±0.21), and (1.58±0.27) vs. (3.29±0.41); t=23.540, 20.151, and 24.383; all P<0.001]. After 3 months' treatment, the levels of osteocalcin (BGP) and bone alkaline phosphatase (BALP) in the observation group were higher than those in the control group [(10.26±1.57) μg/L vs. (8.26±1.02) μg/L and (18.26±1.63) μg/L vs. (16.84±1.29) μg/L; t=7.478 and 4.782; both P<0.001]. The incidence of adverse reactions in the observation group was lower than that in the control group [6.12% (3/49) vs. (10.20% (5/49)], with no statistical difference (χ²=0.136; P=0.712). Conclusion　Jintiange capsules combined with alfacalcitol for elderly patients with OVCF after PKP can significantly improve their clinical symptoms and bone metabolism and reduce their pain degree and scores of traditional Chinese medicine symptoms, and is safe, so it is worth being generalized.

Key words:

Osteoporotic vertebral compression fracture, Jintiange capsules, Alfacalcitol, Percutaneous kyphoplasty of vertebral body

刘日富邹奇冯晓冰刘文成杨广华杨悦黄相杰王雪山.

金天格胶囊和阿法骨化醇于老年OVCF患者PKP术后应用的效果 [J]. 国际医药卫生导报, 2024, 30(9): 1490-1494.

Liu Rifu, Zou Qi, Feng Xiaobing, Liu Wencheng, Yang Guanghua, Yang Yue, Huang Xiangjie, Wang Xueshan.

Effect of Jintiange capsules and alfacalcitol for elderly patients with OVCF after PKP [J]. International Medicine and Health Guidance News, 2024, 30(9): 1490-1494.

参考文献

[1] Ayers C, Kansagara D, Lazur B, et al. Effectiveness and safety of treatments to prevent fractures in people with low bone mass or primary osteoporosis: a living systematic review and network meta-analysis for the American College of Physicians [J]. Ann Intern Med, 2023, 176(2): 182-195. DOI: 10.7326/M22-0684.
[2] 薛磊,马占忠,杨怀阔,等. 自拟益肾壮骨汤联合椎体后凸成形术治疗骨质疏松脊柱压缩性骨折68例[J]. 辽宁中医杂志,2022,49(11):91-94. DOI:10.13192/j.issn.1000-1719. 2022.11.023.
[3] 汪鑫,温伟. 经皮椎体成形术(PVP)、椎体后凸成形术(PKP)治疗老年骨质疏松性椎体压缩性骨折的临床疗效和安全性比较[J]. 中国伤残医学,2021,29(20):24-25. DOI: 10.13214/j.cnki.cjotadm.2021.20.013.
[4] 沈一飞,纪翠芳,李欢,等. 阿法骨化醇联合阿伦磷酸钠维D3片治疗老年骨质疏松的临床疗效及其对骨代谢标志物的影响[J]. 中国老年学杂志,2022,42(11):2710-2712. DOI: 10.3969/j.issn.1005-9202.2022.11.032.
[5] 仇志韬,杨辉,王文革,等. 金天格胶囊联合骨化三醇对骨质疏松性椎体压缩性骨折患者的应用效果分析[J]. 河北医学,2022,28(9):1573-1577. DOI:10.3969/j.issn.1006-6233. 2022.09.035.
[6] 中国人骨质疏松症建议诊断标准(第二稿)[J]. 中国骨质疏松杂志,2000,6(1):1-3.
[7] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.
[8] 刘志雄.骨科常用诊断分类方法和功能结果评定标准[J].北京:北京科学技术出版社, 2005.
[9] He Y, Lin Y, He X, et al. The conservative management for improving Visual Analog Scale (VAS) pain scoring in greater trochanteric pain syndrome: a Bayesian analysis [J]. BMC Musculoskelet Disord, 2023, 24(1): 423. DOI: 10.1186/s12891-023-06443-5.
[10] 汤淑女,尹香君,余卫,等. 中国40岁及以上绝经后女性骨质疏松症患病率及其影响因素研究[J]. 中华流行病学杂志,2022,43(4):509-516. DOI:10.3760/cma.j.cn112338- 20210826-00680.
[11] 丁徐,何汶承,赵毅. 活血益骨汤辅助椎体后凸成形术对老年骨质疏松性胸腰椎骨折患者骨愈合及术后腰椎功能恢复的影响[J]. 国际中医中药杂志,2023,45(7):823-828. DOI:10.3760/cma.j.cn115398-20221121-00326.
[12] 朱玲玲,赵静,李庆凤,等. 依降钙素联合阿法骨化醇治疗老年骨质疏松症的疗效及对患者生活质量和骨相关血清标志物的影响[J]. 临床和实验医学杂志,2022,21(19):2054-2059. DOI:10.3969/j.issn.1671-4695.2022.19.011.
[13] 符芳盈,王隆辉,刘立柱,等.恒古骨伤愈合剂联合碳酸钙D3和阿法骨化醇对老年骨质疏松骨强度及炎症因子的影响[J].中华中医药学刊,2023,41(1):206-209. DOI:10.13193/j.issn.1673-7717.2023.01.047.
[14] 王可可,吴红群,郭浩楠,等. 金天格胶囊联合阿仑膦酸钠对围绝经期骨质疏松症妇女骨代谢生化指标及骨密度的影响分析[J]. 贵州医药,2022,46(11):1756-1757. DOI:10.3969/j.issn.1000-744X.2022.11.045.
[15] 韩昶晓,田向东,朱光宇,等. 金天格胶囊对经皮球囊椎体后凸成形术后患者骨密度、骨代谢及生活质量的影响[J]. 中国骨质疏松杂志,2021,27(1):110-113. DOI:10.3969/j.issn.1006-7108.2021.01.024.

金天格胶囊和阿法骨化醇于老年OVCF患者PKP术后应用的效果

Effect of Jintiange capsules and alfacalcitol for elderly patients with OVCF after PKP

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 3

编辑推荐

Metrics

[1]	张计划张国会刘宇光. 度拉糖肽联合阿法骨化醇对2型糖尿病合并骨质疏松患者的疗效研究 [J]. 国际医药卫生导报, 2024, 30(5): 789-792.
[2]	陈政桑飞姜磊刘青柏. 经皮椎体后凸成形术治疗骨质疏松性椎体骨折的临床疗效 [J]. 国际医药卫生导报, 2023, 29(4): 484-487.
[3]	芦怀旺田霖胡鹏刘彬张玉红. 经皮椎体后凸成形术对新鲜与陈旧性骨质疏松性椎体压缩骨折的临床疗效分析[J]. 国际医药卫生导报, 2022, 28(19): 2730-2735.