关键词:

牙列缺损, 可吸收生物膜, 人工合成骨粉, 牙种植

Abstract:

Objective　To investigate the effect of Bio-Gide absorbable biofilm combined with synthetic bone meal filling for patients taking dental implantation. Methods　Ninety-eight patients with single anterior tooth loss and labial bone defect treated at Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine from January 2020 to April 2022 were selected and divided into a study group and a control group by the random number table method, with 49 cases in each group. The control group included 29 males and 20 females who were (40.95±8.03) years old. The study group included 26 males and 23 females who were (41.37±7.86) years old. The control group took oral repair membrane and synthetic bone meal filling. The study group took Bio-Gide absorbable biofilm combined with synthetic bone meal filling. The implant success rates 3, 6, and 12 months after the implantation, periodontal health and labial bone wall thicknesses before and 12 months after the implantation, bone defect regeneration 3 months after the implantation, levels of gingival crevicular fluid factors before and 3 months after the implantation, and postoperative complications 12 months after the implantation were compared between the two groups. t and χ² tests were applied. Results　There were no statistical differences between the two groups in the implant success rates 3, 6 and 12 months after the implantation and periodontal pocket depth, attachment loss, and gingival bleeding index before the implantation (all P>0.05). Twelve months after the implantation, the gingival bleeding index, periodontal pocket depth, and attachment loss in the study group were lower than those in the control group [(1.01±0.16) vs. (1.13±0.19), (2.19±0.36) mm vs. (2.41±0.42) mm, and (2.01±0.32) mm vs. (2.23±0.38) mm], with statistical differences (all P<0.05). There were no statistical differences in the labial bone thicknesses at the 1, 4, 7, and 10 mm sites between the two groups right after the implantation (all P>0.05); 12 months after the implantation, the labial bone thicknesses at the 1, 4, 7, and 10 mm sites in the study group were higher than those in the control group [(2.21±0.36) mm vs. (2.03±0.34) mm, (2.32±0.41) mm vs. (2.07±0.38) mm, (2.39±0.41)mm vs. (2.13±0.38) mm, and (2.62±0.41) mm vs. (2.31±0.45) mm], with statistical differences (t=2.545, 3.130, 3.256, and 3.565; all P<0.05). Three months after the implantation, the bone graft height and osteogenic height of the study group were higher than those of the control group [(2.71±0.43) mm vs. (2.42±0.39) mm, (2.62±0.41) mm vs. (2.29±0.37) mm], with statistical differences (t=3.497 and 4.183; both P<0.05). There were no statistical differences in the levels of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) between the two groups before the implantation (both P>0.05). Three months after the implantation, the levels of VEGF and BMP-2 in the study group were higher than those in the control group [(46.58±7.12)mg/L vs. (39.56±6.28)mg/L and (486.57±62.18)ng/L vs. (429.84±59.67)ng/L], with statistical differences (t=5.176 and 4.608; both P<0.05). There was no statistical difference in the incidence of total complications between the two groups [8.16% (4/49) vs. 10.20% (5/49); χ²=0.122; P=0.727]. Conclusion　Bio-Gide absorbable biofilm combined with synthetic bone meal for patients taking dental implantation can improve their periodontal health, reduce their bone loss after surgery, and promote the regeneration of bone defects.

Key words:

Dentition defect, Bio-Gide absorbable biofilm, Synthetic bone meal, Dental implantation