一氧化氮与动脉粥样硬化相关性研究进展

doi:10.3760/cma.j.issn.1007-1245.2023.06.003

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (6): 749-752.DOI: 10.3760/cma.j.issn.1007-1245.2023.06.003

一氧化氮与动脉粥样硬化相关性研究进展

程金凤¹ 李洋¹ 王倩倩² 甄萌萌¹ 吴钰婷¹ 程艳丽¹

¹滨州医学院附属医院心内科，滨州　256600；²烟台市烟台山医院心内科，烟台　264000

收稿日期:2022-10-21 出版日期:2023-03-15 发布日期:2023-04-02
通讯作者: 程艳丽，Email：chengyanli0217@163.com
基金资助:
山东省高等学校科技计划项目（J18KB117）

Research progress on correlation between nitric oxide and atherosclerosis

Cheng Jinfeng¹, Li Yang¹, Wang Qianqian², Zhen Mengmeng¹, Wu Yuting¹, Cheng Yanli¹

¹Department of Cardiology, Binzhou Medical University Hospital, Binzhou 256600, China; ²Department of Cardiology, Yantai Yantaishan Hospital, Yantai 264000, China

Received:2022-10-21 Online:2023-03-15 Published:2023-04-02
Contact: Cheng Yanli, Email: chengyanli0217@163.com
Supported by:
Project of Science and Technology Plan of Shandong Higher Education (J18KB117)

摘要/Abstract

摘要：

动脉粥样硬化（AS）是一种常见的动脉血管疾病，是一个复杂的病理过程，同时也是导致冠状动脉疾病（CAD）、心力衰竭、中风等心脑血管疾病的根本原因。一氧化氮（NO）是内皮衍生的舒张因子，是体内第一个被认为是信号传导介质的气体分子，不同条件下生成的NO对AS有抑制或促进作用。该文就内皮型一氧化氮合成酶（eNOS）所生成的NO在AS过程中的作用进行综述。

关键词:

动脉粥样硬化, 一氧化氮, 内皮型一氧化氮合酶

Abstract:

Atherosclerosis (AS) is a common arterial vascular disease; it is a complex pathological process and is the root cause of cardiovascular and cerebrovascular diseases, such as coronary artery disease (CAD), heart failure, and stroke. Nitric oxide (NO), an endothelium-derived relaxation factor, is the first gas molecule in the body that is considered a signaling medium. NO generated under different conditions has an inhibitory or promoting effect on AS. In this paper, we summarize the different roles of NO generated by endothelial nitric oxide synthase (eNOS) in AS process.

Key words:

Atherosclerosis, Nitric oxide, Endothelial nitric oxide synthase

程金凤李洋王倩倩甄萌萌吴钰婷程艳丽.

一氧化氮与动脉粥样硬化相关性研究进展 [J]. 国际医药卫生导报, 2023, 29(6): 749-752.

Cheng Jinfeng, Li Yang, Wang Qianqian, Zhen Mengmeng, Wu Yuting, Cheng Yanli.

Research progress on correlation between nitric oxide and atherosclerosis [J]. International Medicine and Health Guidance News, 2023, 29(6): 749-752.

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一氧化氮与动脉粥样硬化相关性研究进展

Research progress on correlation between nitric oxide and atherosclerosis

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