度普利尤单抗引起超敏反应1例报道并文献复习

doi:10.3760/cma.j.issn.1007-1245.2023.05.023

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (5): 695-697.DOI: 10.3760/cma.j.issn.1007-1245.2023.05.023

度普利尤单抗引起超敏反应1例报道并文献复习

罗育武郎德休周欣张淑娟叶倩如

广州市皮肤病防治所，广州　510095

收稿日期:2022-09-15 出版日期:2023-03-01 发布日期:2023-03-31
通讯作者: 罗育武，Email：1263009@qq.com

Hypersensitivity induced by Dupilumab: a case report and literature review

Luo Yuwu, Lang Dexiu, Zhou Xin, Zhang Shujuan, Ye Qianru

Guangzhou Institute of Dermatology, Guangzhou 510095, China

Received:2022-09-15 Online:2023-03-01 Published:2023-03-31
Contact: Luo Yuwu, Email: 1263009@qq.com

摘要/Abstract

摘要：

本文报道广州市皮肤病防治所度普利尤单抗治疗特应性皮炎（atopic dermatitis，AD）导致超敏反应1例，并对相关文献进行复习总结。患者，男，58岁，因AD首次使用度普利尤单抗治疗，2 d后躯干四肢出现大片红斑和水疱，诊断为多形红斑型药疹。给予系统性甲泼尼松龙治疗后症状好转。度普利尤单抗引起的超敏反应表现是多种多样性的，我们回顾文献汇总类似病例报道并进行总结。

关键词:

度普利尤单抗, 超敏反应, 荨麻疹, 血管性水肿, 血清病样反应, 脱敏

Abstract:

A case of hypersensitivity induced by Dupilumab in the treatment of atopic dermatitis (AD) in Guangzhou Institute of Dermatology was reported, and the relevant literatures were reviewed and summarized. A 58-year-old male patient was treated with Dupilumab for the first time due to AD. Large erythema and blisters appeared on the trunk and limbs 2 days later, and the drug eruption of multiform erythema was diagnosed. He was advised to take systemic methylprednisolone, then tapered slowly based on the response. Hypersensitivity induced by Dupilumab was diverse. We reviewed the literatures and summarized the similar case reports.

Key words:

Dupilumab, Hypersensitivity, Urticaria, Angioedema, Serum sickness-like reaction, Desensitization

罗育武郎德休周欣张淑娟叶倩如.

度普利尤单抗引起超敏反应1例报道并文献复习 [J]. 国际医药卫生导报, 2023, 29(5): 695-697.

Luo Yuwu, Lang Dexiu, Zhou Xin, Zhang Shujuan, Ye Qianru.

Hypersensitivity induced by Dupilumab: a case report and literature review [J]. International Medicine and Health Guidance News, 2023, 29(5): 695-697.

参考文献

[1] Lefevre MA, Nosbaum A. Dermpath and clinic: how to manage adverse reactions to biological agents[J]. Eur J Dermatol, 2021, 31(3):426-427. DOI: 10.1684/ejd.2021. 4070.
[2] Fritz AL, Lacy FA, Morrell DS. Angioedema: a potential complication of dupilumab in atopic dermatitis[J]. Pediatr Dermatol, 2021, 38(1):237-238. DOI: 10.1111/pde.14434.
[3] Treudler R, Delaroque N, Puder M, et al. Dupilumab-induced serum sickness-like reaction: an unusual adverse effect in a patient with atopic eczema[J]. J Eur Acad Dermatol Venereol, 2021, 35(1):e30-e32. DOI: 10.1111/jdv.16782.
[4] Ludriksone L, Elsner P, Schliemann S. Acquired hypersensitivity to dupilumab: first case report[J]. J Eur Acad Dermatol Venereol, 2019, 33(12):e482-e483. DOI: 10.1111/jdv.15807.
[5] Phan M, Linfante A, Kroger K. Ulcerative injection-site reaction associated with dupilumab therapy[J]. JAAD Case Rep, 2020, 6(12):1350-1352. DOI: 10.1016/j.jdcr.2020. 09.022.
[6] Shirley M. Dupilumab: first global approval[J]. Drugs, 2017, 77(10):1115-1121. DOI: 10.1007/s40265-017- 0768-3.
[7] Matsunaga K, Katoh N, Fujieda S, et al. Dupilumab: basic aspects and applications to allergic diseases[J]. Allergol Int, 2020, 69(2):187-196. DOI: 10.1016/j.alit.2020. 01.002.
[8] Jackson K, Bahna SL. Hypersensitivity and adverse reactions to biologics for asthma and allergic diseases[J]. Expert Rev Clin Immunol, 2020, 16(3):311-319. DOI: 10.1080/1744666X.2020.1724089.
[9] Bian S, Zhang P, Li L, et al. Anaphylaxis associated with allergen specific immunotherapy, omalizumab, and dupilumab: a real world study based on the US Food and Drug Administration Adverse Event Reporting System[J]. Front Pharmacol, 2021, 12:767999. DOI: 10.3389/fphar. 2021.767999.
[10] Singh SK, Mahler HC, Hartman C, et al. Are injection site reactions in monoclonal antibody therapies caused by polysorbate excipient degradants?[J]. J Pharm Sci, 2018, 107(11):2735-2741. DOI: 10.1016/j.xphs.2018.07.016.
[11] Pichler WJ. Adverse side-effects to biological agents[J]. Allergy, 2006, 61(8):912-920. DOI: 10.1111/j.1398-9995. 2006.01058.x.
[12] Galvão VR, Castells MC. Hypersensitivity to biological agents-updated diagnosis, management, and treatment[J]. J Allergy Clin Immunol Pract, 2015, 3(2):175-185; quiz 186. DOI: 10.1016/j.jaip.2014.12.006.

度普利尤单抗引起超敏反应1例报道并文献复习

Hypersensitivity induced by Dupilumab: a case report and literature review

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics