关键词:

蛛网膜下腔出血, 依达拉奉注射液, 醒脑静注射液, 神经功能, 疗效

Abstract:

Objective　To investigate the protective effect of edaravone injection combined with Xingnaojing injection on nerve function in patients with subarachnoid hemorrhage and its clinical application value. Methods　A total of 120 patients with subarachnoid hemorrhage treated at Department of Neurology, Xi 'an Daxing Hospital from January 2021 to January 2023 were selected, and were divided into an experimental group and a control group by the random number table method, with 60 cases in each group. There were 38 males and 22 females in the experimental group; they were (67.30±3.13) years old; their disease course was (7.21±0.63) h. There were 33 males and 27 females in the observation group; they were (66.96±2.84) years old; their disease course was (6.49±0.77) h. The control group took routine treatment and intravenously dripped 30 mg of edaravone injection + 100 ml of NaCl injection, twice a day (in the morning and evening); in addition, the experimental group were intravenously dripped 20 ml of Xingnaojing injection + 250 ml of glucose injection, twice a day (in the morning and evening). Both groups were treated for 12 d. The clinical efficacies, inflammatory factors, oxidative stress, and neurological function before and after the treatment, and prognosis were compared between the two groups. χ² and t tests were used for the statistical analysis. Results　The total effective rate of the experimental group was higher than that of the control group [95.00% (57/60) vs. 78.33% (47/60)], with a statistical difference (χ²=7.211; P<0.05). After the treatment, the scores of National Institutes of Health Stroke Scale (NIHSS) and Glasgow Outcome Scale (GOS) in the experimental group were better than those in the control group (8.68±2.21 vs. 14.05±2.27 and 4.30±0.72 vs. 3.07±0.78), with statistical differences (t=13.146 and 9.010; both P<0.05). After the treatment, the levels of hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), and malondialdehyde (MDA) in the experimental group were better than those in the control group, with statistical differences (t=11.379, 12.099, 38.859, and 15.217; all P<0.05). Conclusion　Edaravone injection combined with Xingnaojing injection for patients with subarachnoid hemorrhage can improve their oxidative stress and neurological function, reduce their inflammatory reaction, and increase the clinical treatment effect.

Key words:

Subarachnoid hemorrhage；Edaravone injection；Xingnaojing , injection；Neurological function；Treatment effect