双歧杆菌制剂联合肠内营养治疗重症急性胰腺炎效果的meta分析

doi:10.3760/cma.j.cn441417-20241125-14007

摘要/Abstract

摘要：

目的　评价双歧杆菌制剂联合肠内营养治疗重症胰腺炎的有效性与安全性。方法　检索知网、维普、万方、PubMed、Embase等数据库，筛选临床试验，时间为建库至2024年6月。采用RevMan 5.3软件对纳入的研究进行meta分析，Cochrane handbook5.3评价纳入文献的质量。结果　共纳入19篇随机对照试验，meta分析结果示：两组C反应蛋白（CRP）（SMD=-3.72，95%CI -4.67～-2.78，Z=7.74，P<0.01）、白细胞介素（IL）-6（SMD=-2.44，95%CI -3.38～-1.48，Z=5.07，P<0.01）、IL-8（SMD=-2.66，95%CI -3.68～-1.64，Z=5.13，P<0.01）、肿瘤坏死因子（TNF）-α（SMD=-3.15，95%CI -3.98～-2.33，Z=7.51，P<0.01）、白细胞计数（WBC）（SMD=-1.26，95%CI -1.83～-0.69，Z=4.30，P<0.01）、淀粉酶（AMY）（SMD=-0.98，95%CI=-1.30～-0.66，Z=5.97，P<0.01）、二胺氧化酶（DAO）（SMD=-3.55，95%CI -4.61～-2.49，Z=6.54，P<0.01）、乳酸（Lac）（SMD=-2.93，95%CI -3.76～-2.10，Z=6.93，P<0.01）、内毒素（SMD=-2.26，95%CI -2.83～-1.68，Z=7.63，P<0.01）比水平较，差异均有统计学意义。结论　双歧杆菌制剂联合肠内营养可以有效抑制重症急性胰腺炎患者的炎症反应，降低患者AMY水平，促进患者恢复。

关键词:

双歧杆菌, 肠内营养, 重症急性胰腺炎, meta分析

Abstract:

Objective　To evaluate the efficacy and safety of bifidobacterium preparations and enteral nutrition for severe acute pancreatitis. Methods　China National Knowledge Infrastructure (CNKI), VIP, Wanfang Data, PubMed, and Embase were searched for the clinical trials published from their establishment to June 2024. The RevMan 5.3 software was used for the meta-analysis of the included researches. The Cochrane handbook5.3 was used to evaluate the literature quality. Results　Nineteen randomized controlled trials were included. The meta analysis results showed that there were statistical differences in the levels of C-reactive protein (CRP) (SMD=-3.72, 95%CI -4.67--2.78, Z=7.74, P<0.01), interleukin (IL)-6 (SMD=-2.44, 95%CI -3.38--1.48, Z=5.07, P<0.01), IL-8 (SMD=-2.66, 95%CI -3.68--1.64, Z=5.13, P<0.01), tumor necrosis factor (TNF)-α (SMD=-3.15, 95%CI -3.98--2.33, Z=7.51, P<0.01), white blood cell count (WBC) (SMD=-1.26, 95%CI -1.83--0.69, Z=4.30, P<0.01), amylase (AMY) (SMD=-0.98, 95%CI -1.30--0.66, Z=5.97, P<0.01), diamine oxidase (DAO) (SMD=-3.55, 95%CI -4.61--2.49, Z=6.54, P<0.01), lactic acid (Lac) (SMD=-2.93, 95%CI -3.76--2.10, Z=6.93, P<0.01, and endotoxin (SMD=-2.26, 95%CI -2.83--1.68, Z=7.63, P<0.01) between the two groups. Conclusions　Bifidobacterium preparations combined with enteral nutrition can effectively inhibit the inflammatory response of patients with severe acute pancreatitis, reduce the level of AMY, and promote their recovery.

Key words: Bifidobacterium preparations, , Enteral nutrition, , Severe acute pancreatitis, , Meta-analysis

李洋周泽刘金响史英马小兵荆志强.

双歧杆菌制剂联合肠内营养治疗重症急性胰腺炎效果的meta分析 [J]. 国际医药卫生导报, 2025, 31(14): 2317-2323.

Li Yang, Zhou Ze, Liu Jinxiang, Shi Ying, Ma Xiaobing, Jing Zhiqiang.

Bifidobacterium preparations combined with enteral nutrition for severe acute pancreatitis: a meta-analysis [J]. International Medicine and Health Guidance News, 2025, 31(14): 2317-2323.

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