International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (20): 2902-2905.DOI: 10.3760/cma.j.issn.1007-1245.2022.20.019

• Special Column of Urology and Reproduction • Previous Articles     Next Articles

Research progress of immunomodulation in idiopathic membranous nephropathy and podocyte injury

Chen Qu, Wang Xuebin   

  1. Department of Rheumatology and Immunology, Binzhou Medical University Hospital, Binzhou 256603, China
  • Received:2022-07-09 Online:2022-10-15 Published:2022-10-14
  • Contact: Wang Xuebin, Email: wxbbyfy@163.com
  • Supported by:
    Graduate Education Innovation Program Project of Shandong Provincial Department of Education (20038607)

免疫调节在特发性膜性肾病及足细胞损伤中的研究进展

陈瞿  王学彬   

  1. 滨州医学院附属医院风湿免疫科,滨州 256603
  • 通讯作者: 王学彬,Email:wxbbyfy@163.com
  • 基金资助:
    山东省教育厅研究生教育创新计划项目(20038607)

Abstract: Idiopathic membranous nephropathy is a common immune-mediated glomerular disease. It is one of the common pathological types of adult nephrotic syndrome, and also one of the main causes of chronic kidney disease and end-stage renal disease. The podocytes are the central target of proteinuria in idiopathic membranous nephropathy, and the podocyte injury is an important factor in the progressive development of idiopathic membranous nephropathy, in which immune complex deposition and internal environment play a key role. This article reviews the pathogenesis of immunomodulation in idiopathic membranous nephropathy and podocyte injury.

Key words: Idiopathic membranous nephropathy, Immunomodulation, Internal environment, Podocytes, Pathogenesis

摘要: 特发性膜性肾病是一种常见的免疫介导的肾小球疾病,是成年人肾病综合征常见的病理类型之一,也是导致慢性肾脏病和终末期肾脏病的主要病因之一。足细胞是特发性膜性肾病蛋白尿发生的中心靶点,足细胞损伤是特发性膜性肾病进行性发展的重要因素,其中免疫复合物沉积及内环境发挥关键作用。本文对免疫调节在特发性膜性肾病及足细胞损伤中的发病机制进行综述。

关键词: 特发性膜性肾病, 免疫调节, 内环境, 足细胞, 发病机制