Correlation between vitamin D level and cognitive dysfunction in elderly
patients with cerebral small vessel disease

doi:10.3760/cma.j.issn.1007-1245.2022.08.010

International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (8): 1081-1085.DOI: 10.3760/cma.j.issn.1007-1245.2022.08.010

• Scientific Research • Previous Articles Next Articles

Correlation between vitamin D level and cognitive dysfunction in elderly patients with cerebral small vessel disease

Gong Chen, Shen Xiaozhu, Bao Qinwen, Zhao Xiaofei

Department of Geriatrics, The Second People's Hospital of Lianyungang City, Kangda College Affiliated Hospital of Nanjing Medical University, Lianyungang 222000, China

Received:2022-01-17 Online:2022-04-15 Published:2022-05-09
Contact: Zhao Xiaofei, Email: 462171800@qq.com
Supported by:
Scientific Research and Development Fund of Kangda College, Nanjing Medical University (KD2019KYJJYB020);

Key Research and Development Program (Social Development) of Lianyungang Science and Technology Bureau (SE2126);

Science and Technology Project of Health Commission of Lianyungang City (202024);

Jiangsu Province "Six One Project" Top-Notch Talent Project (LGY2019062)

维生素D水平与老年脑小血管病患者认知功能障碍的相关性研究

龚晨申潇竹包勤文赵晓斐

连云港市第二人民医院南京医科大学康达学院附属医院老年医学科，连云港　222000

通讯作者: 赵晓斐，Email：462171800@qq.com
基金资助:
南京医科大学康达学院科研发展基金（KD2019KYJJYB020）；

连云港市科学技术局重点研发计划（社会发展）项目（SE2126）；

连云港市卫生健康委员会科技项目（202024）；

江苏省“六个一工程”拔尖人才拟资助项目（LGY2019062）

Abstract

Abstract: Objective　To investigate the correlation between serum 25-hydroxyvitamin D [25(OH)D] level and cognitive dysfunction in elderly patients with cerebral small vessel disease (CSVD). Methods　From December 2019 to December 2020, 97 patients with CSVD in The Second People's Hospital of Lianyungang City including 56 males and 41 females, aged 65-85 years were selected and were divided into a CSVD with normal cognition group (50 cases) and a CSVD with cognitive dysfunction group (47 cases) according to the Montreal Cognitive Assessment Scale (MoCA) score, and other 30 elderly healthy people were selected as a control group. The clinical data and serum 25(OH)D levels of the three groups were collected. One way ANOVA was used for comparison of the measurement data between groups, χ² test was used for comparison of the count data between groups. Multivariate logistic regression analysis was used to analyze the risk factors for cognitive dysfunction in CSVD patients, and Pearson correlation analysis was used to explore the relationship between the MoCA score and 25(OH)D level in the cognitive dysfunction group. Results　The 25(OH)D levels of the CSVD with normal cognition group [(23.36±2.10) μg/L] and the CSVD with cognitive dysfunction group [(15.66±1.47) μg/L] were lower than that of the control group [(34.03±2.17) μg/L] (F=13.764, P<0.05), and the level of 25(OH)D in the CSVD with cognitive dysfunction group was significantly lower than that in the CSVD with normal cognition group (P<0.05). Compared with those in the CSVD with normal cognition group and the control group, the scores of visual space and execution, attention and computation, abstraction, delayed recall, and orientation and the total score of MoCA were decreased in the CSVD with cognitive dysfunction group (all P<0.05). Multivariate logistic regression analysis showed that 25(OH)D level was a protective factor for cognitive dysfunction in elderly patients with CSVD (OR=0.491, P=0.005). In the CSVD with cognitive dysfunction group, the level of 25(OH)D was positively correlated with the total score of MoCA and the scores of visual space and execution, attention and computation, delayed recall, and orientation (r=0.74, 0.63, 0.59, 0.74, 0.53; all P<0.05). Conclusion　The decline of serum 25(OH)D level is a risk factor for cognitive dysfunction in elderly patients with CSVD, and patients with low serum 25(OH)D level have more obvious cognitive dysfunction.

Key words: 25(OH)D, Cerebral small vessel disease, Cognitive dysfunction

摘要： 目的　分析老年脑小血管病（CSVD）患者的血清25-羟基维生素D［25（OH）D］水平与认知功能障碍之间的关系。方法　选择2019年12月至2020年12月于连云港市第二人民医院就诊的老年CSVD患者共97例，其中男56例、女41例，年龄65～85岁，依据蒙特利尔认知评估量表（MoCA）评分结果，分为CSVD认知正常组（50例）、CSVD认知障碍组（47例），另选取同期健康老年人群作为对照组（30例），收集3组受试者的临床资料和测定血清25（OH）D水平。计量资料组间比较采用单因素方差分析，计数资料组间比较采用χ²检验，多因素logistic回归分析分析CSVD患者出现认知功能障碍的危险因素，Pearson相关性分析分析认知障碍组MoCA评分与25（OH）D水平的关系。结果　CSVD认知正常组［（23.36±2.10）μg/L］、CSVD认知障碍组［（15.66±1.47）μg/L］25（OH）D水平较对照组［（34.03±2.17）μg/L］降低（F=13.764，P<0.05），且CSVD认知障碍组的25（OH）D水平明显低于CSVD认知正常组水平（P<0.05）；此外，CSVD认知障碍组在视空间与执行、注意力及计算力、抽象、延迟回忆、定向力评分和MoCA总分方面较CSVD认知正常组、对照组下降（均P<0.05）。多因素logistic回归分析结果示25（OH）D水平是老年CSVD患者认知功能障碍的保护因素（OR=0.491，P=0.005）。CSVD认知障碍组患者中25（OH）D水平与MoCA总分及视空间与执行、注意力及计算力、延迟回忆、定向力评分呈正相关（r=0.74、0.63、0.59、0.74、0.53，均P<0.05）。结论　血清25（OH）D水平降低是老年CSVD患者出现认知功能障碍的危险因素，低25（OH）D水平者认知障碍更明显。

关键词: 25（OH）D, 脑小血管病, 认知功能障碍

Gong Chen, Shen Xiaozhu, Bao Qinwen, Zhao Xiaofei. Correlation between vitamin D level and cognitive dysfunction in elderly patients with cerebral small vessel disease[J]. International Medicine and Health Guidance News, 2022, 28(8): 1081-1085.

龚晨, 申潇竹, 包勤文, 赵晓斐. 维生素D水平与老年脑小血管病患者认知功能障碍的相关性研究[J]. 国际医药卫生导报, 2022, 28(8): 1081-1085.

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Correlation between vitamin D level and cognitive dysfunction in elderly patients with cerebral small vessel disease

维生素D水平与老年脑小血管病患者认知功能障碍的相关性研究

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