Abstract:

Objective　To study the effect of self-prepared Yinqiao Qingjie Decoction combined with intense pulsed light on facial skin microecology of patients with rosacea. Methods　One hundred patients with rosacea treated in Ankang Traditional Chinese Medicine Hospital from June 2022 to August 2023 were selected for the randomized controlled trial, and were divided into a control group and an experimental group by the random number table method, with 50 cases in each group. There were 27 males and 23 females in the control group; they were (40.60±9.75) years old. There were 26 males and 24 females in the experimental group; they were (40.30±9.62) years old. The control group group were treated with intense pulsed light, and the experimental group with intense pulsed light and Yinqiao Qingjie Decoction. Both groups were treated continuously for 3 months. The clinical efficacies, scores of traditional Chinese medicine symptoms, facial skin microecological changes, and serum levels of inflammatory factors [interleukin (IL)-6, tumor necrosis factor-α (TNF-α), IL-17, and IL-23] were compared between the two groups by t and χ². Results　The total effective rate of the experimental group was higher than that of the control group [96.00% (48/50) vs. 82.00% (41/50)], with a statistical difference (χ²=5.005; P=0.025). After 3 months' treatment, the scores of papules and pustules, scalding, erythema, and itch, pH of facial skin, sebum secretion rate, and levels of IL-6, TNF-α, IL-17, and IL-23 in the experimental group were lower than those in the control group [1.60±0.45 vs. 2.50±0.67, 1.22±0.31 vs. 2.08±0.45, 1.20±0.36 vs. 2.12±0.46, 1.16±0.34 vs. 2.04±0.68, 5.12±0.25 vs. 5.34±0.31, (1.40±0.25) μg/(cm²·min) vs. (1.68±0.29) μg/(cm²·min), (19.53±5.23) ng/L vs. (25.71±7.21) ng/L, 30.48±6.82) ng/L vs. (41.20±8.01) ng/L, (34.51±6.21)ng/L vs. (43.97±8.62) ng/L, and (46.28±5.88) ng/L vs. (61.39±9.21) ng/L], with statistical differences (t=7.885, 11.129, 11.137, 8.185, 3.906, 5.171, 4.906, 7.205, 6.296, and 9.778; all P<0.05). Conclusion　Self-prepared Yinqiao Qingjie Decoction combined with intense pulsed light for patients with rosacea is effective and can improve their facial skin microecology and inflammatory response.

Key words:

Rosacea；Self-prepared Yinqiao Qingjie , Decoction；Intense pulsed light；Facial skin microecology；Inflammatory factors

摘要：

目的　探讨自拟银翘清解汤联合强脉冲光对玫瑰痤疮患者面部皮肤微生态的影响。方法　选取2022年6月至2023年8月安康市中医医院收治的100例玫瑰痤疮患者进行随机对照试验，采用随机数字表法将其分为对照组和试验组，各50例。对照组男27例、女23例，年龄（40.60±9.75）岁，开展强脉冲光治疗；试验组男26例、女24例，年龄（40.30±9.62）岁，在对照组基础上增用自拟银翘清解汤治疗。两组均连续治疗3个月。对比两组临床疗效、中医症状积分、面部皮肤微生态变化状况及血清炎症因子水平［白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-17（IL-17）、白细胞介素-23（IL-23）］。统计学方法采用t检验、χ²检验。结果　试验组总有效率高于对照组［96.0%（48/50）比82.0%（41/50）］，差异有统计学意义（χ²=5.005，P=0.025）。治疗后，试验组丘疹脓包、灼热、红斑、瘙痒评分，面部皮肤pH值、皮脂分泌率（SER），IL-6、TNF-α、IL-17、IL-23水平分别为（1.60±0.45）分、（1.22±0.31）分、（1.20±0.36）分、（1.16±0.34）分，5.12±0.25、（1.40±0.25）μg/（cm²·min），（19.53±5.23）ng/L、（30.48±6.82）ng/L、（34.51±6.21）ng/L、（46.28±5.88）ng/L，均低于对照组［（2.50±0.67）分、（2.08±0.45）分、（2.12±0.46）分、（2.04±0.68）分，5.34±0.31、（1.68±0.29）μg/（cm²·min），（25.71±7.21）ng/L、（41.20±8.01）ng/L、（43.97±8.62）ng/L、（61.39±9.21）ng/L］，差异均有统计学意义（t=7.885、11.129、11.137、8.185、3.906、5.171、4.906、7.205、6.296、9.778，均P<0.05）。结论　自拟银翘清解汤联合强脉冲光治疗玫瑰痤疮患者疗效较好，可显著改善患者面部皮肤微生态及炎症反应。

关键词:

玫瑰痤疮, 自拟银翘清解汤, 强脉冲光, 面部皮肤微生态, 炎症因子