Abstract:

Objective　To investigate the correlation of cognitive function with the levels of interleukin-1β (IL-1β), α-synuclein, and thioredoxin peroxidase (TPX) and pain in patients with primary Parkinson's disease. Methods　This was a retrospective study. The clinical data of 124 patients with primary Parkinson's disease treated at Xi'an Honghui Hospital between March 2021 and March 2024 were collected. Among them, there were 75 males and 49 females, with an age of 63.84±7.47. According to their cognitive function, they were divided into a PDCI group (51 cases, dementia) and a PDNC group (73 cases, mild cognitive impairment and no cognitive impairment). The serum levels of IL-1β, α-synuclein, and TPX in both groups were measured using the enzyme linked immunosorbent assay. The Montreal Cognitive Assessment (MoCA) and KINGs' Parkinsons' Disease Pain Scale (KPPS) were used to evaluate their cognitive function and pain. The receiver operating characteristic curve (ROC) was used to assess the value of the levels of IL-1β, α-synuclein, and TPX and score of KPPS in the evaluation of incidence of dementia. Paired t and χ² tests were used for the statistical analysis. Results　The patients in the PDCI group were older than the patients in the PDNC group (P<0.05). The serum levels of IL-1β and α-synuclein and score of KPPS in the PDCI group were higher were higher than those in the PDNC group (all P<0.05). The level of TPX in the PDCI group was lower than that in the PDNC group (P<0.05). The scores of all the dimensions and total score of MoCA in the PDCI group were lower than those in the PDNC group (all P<0.05). The total score of MoCA was negatively correlated with serum IL-1β and α-synuclein and score of KPPS (r=-0.413, -0.553, and -0.691; all P<0.05), and positively with serum TPX (r=0.799; P<0.05). The ROC analysis indicated that the combination of IL-1β, α-synuclein, TPX, and score of KPPS had an area under the curve of 0.973, a sensitivity of 98.0%, and a specificity of 97.3%. Conclusion　The abnormal expression of serum IL-1β, α-synuclein, and TPX, as well as pain symptoms, are closely related to cognitive impairment in patients with primary Parkinson's disease.

Key words:

Interleukin-1β, α-synuclein, Thioredoxin peroxidase, Cognitive function, Pain, Primary Parkinson's disease

摘要：

目的　探讨原发性帕金森病患者血清中白细胞介素-1β（IL-1β）、α-突触核蛋白和硫氧还蛋白硫过氧化物酶（TPX）的表达水平及疼痛与认知功能损害的相关性。方法　本研究采用回顾性分析，收集2021年3月至2024年3月期间西安市红会医院收治的124例原发性帕金森病患者的临床资料。其中男75例、女49例，年龄（63.84±7.47）岁。根据认知功能状态分为PDCI组（51例，痴呆）和PDNC组（73例，轻微认知障碍和无认知障碍）。通过酶联免疫吸附试验法测定两组间血清IL-1β、α-突触核蛋白和TPX的表达水平，采用蒙特利尔认知评估量表（MoCA）、KINGS帕金森病疼痛量表（KPPS）对患者认知功能与疼痛症状进行评分，采用Pearson相关性分析认知功能与血清IL-1β、α-突触核蛋白、TPX表达水平及KPPS评分的相关性。通过受试者操作特征曲线（ROC）评估IL-1β、α-突触核蛋白、TPX水平及KPPS评分在评估原发性帕金森患者发生痴呆中的价值。采用配对t检验、χ²检验进行统计分析。结果　PDCI组患者年龄大于PDNC组，血清IL-1β和α-突触核蛋白水平及KPPS评分高于PDNC组，TPX水平低于PDNC组（均P<0.05）。PDCI组患者的MoCA量表各维度及总分均低于PDNC组（均P<0.05）。MoCA总分与血清IL-1β、α-突触核蛋白和KPPS评分存在负相关（r=-0.413、-0.553、-0.691，均P<0.05），MoCA总分与血清TPX存在正相关（r=0.799，P<0.05）。ROC表明，IL-1β、α-突触核蛋白、TPX及KPPS评分联合预测的曲线下面积（AUC）值为0.973，灵敏度为98.0%，特异度为97.3%。结论　血清IL-1β、α-突触核蛋白和TPX的表达异常及疼痛症状与原发性帕金森病患者的认知功能损害密切相关。

关键词:

白细胞介素-1β, α-突触核蛋白, 硫氧还蛋白硫过氧化物酶, 认知功能, 疼痛, 原发性帕金森病