Research progress of semaglutide in treatment of obesity

doi:10.3760/cma.j.issn.1007-1245.2022.07.003

Abstract

Abstract: Obesity has become a serious public health crisis in the whole world, and its incidence is increasing. Obesity and a series of concurrent diseases bring huge burden to the health care system. How to lose weight more effectively has become a hot spot in today's society, and it is difficult to control body weight only by life intervention. Therefore, anti-obesity drugs as an auxiliary means have received widespread attention, but relatively few drugs have been approved for weight loss. Semaglutide, a new glucagon-like peptide-1 receptor agonist (GLP-1RA), has the advantages of long half-life and high stability as compared with traditional GLP-1RA. This article focuses on the research progress of semaglutide in the treatment of obesity, which provides a new choice for reducing obesity.

Key words: Semaglutide, Obesity, Glucagon-like peptide-1 receptor agonist

摘要： 全球范围内，肥胖已经成为一个严重的公共健康危机，且发病率不断增高。肥胖和一系列并发疾病给医疗保健系统带来了巨大负担，如何更有效减轻体质量已经成为当今社会的一个热点，仅靠单纯的生活干预很难控制，因此作为辅助手段的抗肥胖药物受到广泛的关注，但目前被批准用于减轻体资料的药物相对较少。司美格鲁肽是一种新型的胰高血糖素样肽-1受体激动剂（glucagon-like peptide-1 receptor agonist，GLP-1RA），相比传统的GLP-1RA，其具有半衰期长、稳定性高等优点。本文重点以司美格鲁肽治疗肥胖的研究进展进行讨论，为减轻肥胖提供一种新选择。

关键词: 司美格鲁肽, 肥胖, 胰高血糖素样肽-1受体激动剂

Xing Guoqing, Yu Suguo. Research progress of semaglutide in treatment of obesity[J]. International Medicine and Health Guidance News, 2022, 28(7): 898-901.

邢国庆, 于苏国. 司美格鲁肽治疗肥胖的研究进展[J]. 国际医药卫生导报, 2022, 28(7): 898-901.

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