Abstract:

Objective　To analyze the effect of iRoot SP combined with single pointed root canal filling in the treatment of patients with retrograde pulpitis. Methods　A total of 120 patients with retrograde pulpitis who were treated in Department of Stomatology, Fujian Provincial Hospital from January 2022 to May 2023 were selected for the randomized controlled trial, and were divided into a control group and an observation group by the random number table method, with 60 cases in each group. There were 35 males and 25 females in the control group; they were (58.65±4.89) years old; their disease course was (4.12±1.36) years. There were 32 males and 28 females in the observation group; they were (59.34±5.27) years old; their disease course was (4.51±1.49) years. The control group received root canal filling using iRoot SP by the cold lateral pressure method. The observation group used iRoot SP and did single pointed root canal filling. The therapeutic effects, filling effects, periodontal indices [probing depth (PD), probing bleeding index (BOP), tooth mobility (TM), and clinical attachment level (CAL)], and levels of inflammatory factors [hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β)] in gingival crevicular fluid were compared between the two groups. t and χ² tests were applied. Results　The total effective rate of the observation group was higher than that of the control group [96.67% (58/60) vs. 86.67% (52/60)], with a statistical difference (χ²=3.927; P<0.05). The good filling rate of the observation group was higher than that of the control group [96.67% (58/60) vs. 75.00% (45/60)], with a statistical difference (χ²=11.582; P<0.05). Before the treatment, there were no statistical differences in the PD, BOP, TM, CAL, and levels of hs-CRP, TNF-α, and IL-1β between the two groups (all P>0.05). After the treatment, the PD, BOP, TM, CAL, and levels of hs-CRP, TNF-α, and IL-1β in the observation group were lower than those in the control group [(1.97±0.23) mm vs. (2.76±0.26) mm, (0.84±0.19) vs. (1.31±0.23), (0.12±0.05) mm vs. (0.27±0.08) mm, (0.94±0.37) mm vs. (2.10±0.42) mm, (0.78±0.06)mg/L vs. (1.03±0.09) mg/L, (0.48±0.09) mg/L vs. (1.01±0.10) mg/L, and (56.68±2.34) ng/L vs. (63.16±2.57) ng/L], with statistical differences (t=17.628, 12.203, 12.316, 16.053, 17.903, 30.515, and 14.441; all P<0.05). Conclusion　iRoot SP combined with single pointed root canal filling treatment for patients with retrograde pulpitis has good root canal sealing effect and can improve their periodontal status and inflammatory factor levels in gingival crevicular fluid of affected teeth, with significant overall therapeutic effect.

Key words:

Retrograde pulpitis, IRoot SP, Single pointed root canal filling, Periodontal index, Inflammatory factor levels

摘要：

目的　分析iRoot SP配合单尖法根管充填治疗逆行性牙髓炎的效果。方法　前瞻性研究，选取2022年1月至2023年5月在福建省立医院口腔科治疗的逆行性牙髓炎患者120例作为研究对象，按照随机数字表法分为对照组和观察组，各60例。对照组男35例、女25例，年龄（58.65±4.89）岁，病程（4.12±1.36）年，以iRoot SP配合冷侧方加压法根管充填；观察组男32例、女28例，年龄（59.34±5.27）岁，病程（4.51±1.49）年，以iRoot SP配合单尖法根管充填。对比两组疗效、充填效果、牙周指数［牙周探诊深度（PD）、探诊出血指数（BOP）、牙齿松动度（TM）、临床附着水平（CAL）］及龈沟液炎性因子水平［超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）］。统计学方法采用t检验、χ²检验。结果　观察组治疗总有效率为96.67%（58/60），高于对照组的86.67%（52/60），差异有统计学意义（χ²=3.927，P<0.05）。观察组填充良好率为96.67%（58/60），高于对照组的75.00%（45/60），差异有统计学意义（χ²=11.582，P<0.05）。治疗前，两组患者PD、BOP、TM、CAL及hs-CRP、TNF-α、IL-1β水平比较，差异均无统计学意义（均P>0.05）；治疗后，观察组PD、BOP、TM、CAL及hs-CRP、TNF-α、IL-1β水平均低于对照组［（1.97±0.23）mm比（2.76±0.26）mm、（0.84±0.19）分比（1.31±0.23）分、（0.12±0.05）mm比（0.27±0.08）mm、（0.94±0.37）mm比（2.10±0.42）mm、（0.78±0.06）mg/L比（1.03±0.09）mg/L、（0.48±0.09）mg/L比（1.01±0.10）mg/L、（56.68±2.34）ng/L比（63.16±2.57）ng/L］，差异均有统计学意义（t=17.628、12.203、12.316、16.053、17.903、30.515、14.441，均P<0.05）。结论　iRoot SP配合单尖法根管充填治疗逆行性牙髓炎，根管封闭效果较好，可改善患者牙周状态及龈沟液炎性因子水平，整体疗效显著。

关键词:

逆行性牙髓炎, iRoot SP, 单尖法根管充填, 牙周指数, 炎性因子水平