Abstract:

Objective　To evaluate the relationships of ABO blood types with ovarian cancer onset, International Federation of Gynecology and Obstetrics (FIGO) staging, pathological types. Methods　The relevant clinical data of 285 patients with ovarian cancer who underwent initial surgery and were pathologically diagnosed at Second Hospital, Shaanxi University of Traditional Chinese Medicine were enrolled, including age, menopausal status, presence of malignant ascites, FIGO staging, pathological types, serum carcinoembryonic antigen carcinoembryonic antigen (CA) 125, and blood types. Three hundred patients with benign ovarian tumors during the same period were selected as the controls. The relationships of ABO blood types with ovarian cancer onset risk, FIGO staging, and pathological types were retrospectively analyzed. Kolmogorov Smirnov test, F test, χ² test, and Fisher exact probability were used. Results　Among the 285 patients with ovarian cancer, there were 83 cases (29.1%) of blood type A, 95 cases (33.3%) of type B, 72 cases (25.3%) of type O, and 35 cases (12.3%) of type AB. Among the 300 patients with benign ovarian tumors, there were 77 cases (25.7%) blood type A, 90 cases (30.0%) of type B, 99 cases (33.0%) of type O, and 34 cases (11.3%) of type AB. Type O accounted the highest proportion in the patients with benign ovarian tumors, and type B in the patients with ovarian cancer. There were no statistical differences in age, FIGO staging, pathological types, menopausal status, and CA125 level between the patients of different blood types (all P>0.05). The logistic regression model showed that blood type B was a risk factor for ovarian cancer in the patients (OR=3.518, 95%CI 1.519-8.146, P<0.05). ABO blood types did not correlate with FIGO staging and pathological type of ovarian cancer (both P>0.05). Conclusions　Blood type B is the most common type in patients with ovarian cancer, and is associated with an increased risk of ovarian cancer. ABO blood types do not correlate with FIGO staging and pathological type of ovarian cancer

Key words:

Ovarian cancer, ABO blood types, Risk

摘要：

目的　评估ABO血型与卵巢癌的发病、国际妇产科联盟（FIGO）分期及病理分型的关系。方法　收集2012年6月至2023年6月期间在陕西中医药大学第二附属医院确诊且经过初次手术的285例卵巢癌患者临床资料，包括年龄、绝经状态、是否合并恶性腹水，FIGO分期、病理类型、血清癌胚抗原125（CA125）、血型等。选取同期300例卵巢良性肿瘤患者作为对照。回顾性分析ABO血型与卵巢癌发病风险、FIGO分期、病理类型等临床指标之间的关系。采用Kolmogorov-Smirnov检验、F检验、χ²检验、Fisher确切概率法进行统计比较。结果　285例卵巢癌患者中，A、B、O和AB型分别为83例（29.1%）、95例（33.3%）、72例（25.3%）和35例（12.3%）。300例卵巢良性肿瘤患者中，A、B、O和AB型分别为77例（25.7%）、90例（30.0%）、99例（33.0%）、34例（11.3%）。O型血在良性肿瘤中占比最高，B型血在卵巢癌患者中占比最高。不同血型卵巢癌患者的年龄、FIGO分期、病理分型、绝经状态、CA125比较，差异均无统计学意义（均P>0.05）。logistic回归模型显示，B型血是卵巢癌患者发病的风险因素（OR=3.518，95%CI=1.519～8.146，P<0.05）。ABO血型与卵巢癌的FIGO分期、病理类型无明显相关性（均P>0.05）。结论　B型血是卵巢癌患者中较常见的血型，与卵巢癌风险增加有关；ABO血型与卵巢癌的FIGO分期、病理分型无明显关系。

关键词:

卵巢癌, ABO血型, 风险