Research progress of clinical application of circulating tumor cells in hepatocellular carcinoma

doi:10.3760/cma.j.issn.1007-1245.2024.11.017

Abstract

Abstract:

Hepatocellular carcinoma (HCC) is one of the common malignant tumors of the digestive system, characterized by insidious onset, high malignancy, and poor prognosis. Early diagnosis and accurate evaluation of HCC can effectively guide clinical treatment, so as to improve the patients' overall clinical prognosis. Circulating tumor cell (CTC) testing is an important part of the liquid biopsy technology. CTC detection is a simple and accurate method, and can replace biopsy in diagnosing HCC partly. At the same time, CTC detection has also shown important application value in the clinical prognosis assessment of HCC patients, especially in the evaluation of postoperative recurrence of surgical patients. With the continuous development of CTC detection technology, its value in the clinical diagnosis and treatment of HCC will be further expanded, so that more HCC patients can benefit from it.

Key words:

Hepatocellular carcinoma, Liquid biopsy, Circulating tumor cells, CellSearch^?, Diagnosis, Prognosis

摘要：

肝细胞癌（hepatocellular carcinoma，HCC）是常见的消化系统恶性肿瘤之一，具有起病隐匿、恶性程度高、临床预后差的特点。对HCC的早期诊断及准确评估可以有效指导临床实施针对性的干预措施，从而最大限度地改善患者的临床总体预后。循环肿瘤细胞（circulating tumor cell，CTC）检测属于新型液体活检技术的重要组成，其检测方法简便，结果准确可靠，在一定程度上可以替代活组织检查作为HCC诊断的指标。同时，通过CTC检测在HCC患者临床预后评估，尤其是手术患者术后复发评估方面也显示出了重要的应用价值。随着CTC检测技术的不断发展，其用于HCC临床诊治方面的价值也将得到进一步的拓展，从而使更多的HCC患者从中获益。

关键词:

肝细胞癌, 体液活检, 循环肿瘤细胞, CellSearch^?, 诊断, 预后

Zhu Peng, Wu Lili, Guo Shimin.

Research progress of clinical application of circulating tumor cells in hepatocellular carcinoma [J]. International Medicine and Health Guidance News, 2024, 30(11): 1844-1848.

朱鹏吴莉莉郭世民.

循环肿瘤细胞在肝细胞癌中的临床应用研究进展 [J]. 国际医药卫生导报, 2024, 30(11): 1844-1848.

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