Abstract:

Objective　To investigate the relevant influencing factors of depression in patients with hematological malignancies. Methods　In the present cross-sectional study, 102 patients with hematological malignancies admitted to Department of Hematology, Guangzhou Panyu Central Hospital from April 2021 to June 2023 were selected. Their basic information was collected through a questionnaire survey, including gender, age, and education level. Hamilton Depression Rating Scale (HAMD) 17 was used to assess their depression status. The patients were divided into two groups according to whether they suffered from depression or not. Univariate analysis was performed by χ² test to screen out the influencing factors with P<0.05, and multivariate analysis was performed by binary logistic regression analysis to obtain the independent influencing factors. Results　In the 102 patients, males accounted for 56.86% (58/102), and the age was (53.23±16.37) years old. Among them, 64 patients had HAMD 17 score ≥7 points, with the incidence of depression of 62.75%. There were statistically significant differences between the two groups in factors such as education level (χ²=12.004), chemotherapy times (χ²=16.997), and disease status (χ²=8.847) (all P<0.05). The above factors were included in logistic regression analysis, and it was concluded that education level and chemotherapy times were independent influencing factors for hematological malignancies related depression (both OR>1, P<0.05). Conclusions　The occurrence of depressive symptoms in patients with hematological malignancies is closely related to multiple factors. In clinical practice, it is necessary to pay attention to patients with high-risk factors and actively provide intervention measures to prevent the occurrence of depression.

Key words:

Depression, Hematological malignancies, Hamilton Depression Scale, Epidemiology, Influencing factors

摘要：

目的　分析血液恶性肿瘤患者并发抑郁的相关影响因素。方法　采用横断面研究，选取广州市番禺区中心医院血液科2021年4月至2023年6月收治的血液恶性肿瘤患者102例，使用问卷调查的方式采集基本信息，包括性别、年龄、文化程度等。使用17项汉密尔顿抑郁量表（HAMD 17）评估其抑郁情况。根据患者是否患有抑郁分成两组，采用χ²检验进行单因素分析，筛选出P<0.05的影响因素；采用二元logistic回归分析进行多因素分析，得出独立影响因素。结果　102例患者中男性占比56.86%（58/102），年龄为（53.23±16.37）岁。其中HAMD 17 ≥7分的患者64例，抑郁发生率为62.75%。两组的文化程度（χ²=12.004）、化疗次数（χ²=16.997）、疾病状态（χ²=8.847）比较差异均有统计学意义（均P<0.05）。将上述因素纳入logistic回归分析，最后得出文化程度、化疗次数是血液恶性肿瘤相关性抑郁的独立影响因素（均OR>1，P<0.05）。结论　血液恶性肿瘤患者抑郁的发生与多种因素密切相关，临床需要重视存在高危因素的患者，积极给予干预措施预防抑郁的发生。

关键词:

抑郁, 血液恶性肿瘤, 汉密尔顿抑郁量表, 流行病学, 影响因素