Abstract:

Objective　To study the value of microRNA-208 (miR-208) in the early diagnosis of acute myocardial infarction (AMI) in clinical practice. Methods　PubMed, Medline, Web of Science, CNKI, and Wanfang databases were searched for literatures on the diagnosis of AMI by miR-208 from the establishment of the databases to January 20, 2021. Meta-analysis of the literatures was performed by using MetaDisc 1.4 software and RevMan 5.3. Results　Ten studies of moderate to high quality were included. The combined sensitivity of miR-208 for diagnosing AMI was 0.77 (95%CI 0.74-0.79), the specificity was 0.84 (95%CI 0.82-0.86), and the area under the summary receiver operating characteristic curve (SROC-AUC) was 0.894 2. Conclusion　As a novel marker, miR-208 has high sensitivity and specificity for early diagnosis of AMI, which can assist in the early diagnosis of AMI.

Key words:

Acute myocardial infarction, miR-208, Early diagnosis, Meta-analysis

摘要：

目的　研究微RNA-208（miR-208）在临床中早期诊断急性心肌梗死（AMI）的价值。方法　检索PubMed、Medline、Web of Science、中国知网和万方数据从建库起至2021年1月20日发表的关于miR-208诊断AMI的文献资料。用MetaDisc 1.4软件和RevMan 5.3对文献进行meta分析。结果　共纳入10篇中高水平质量研究。miR-208诊断AMI的合并灵敏度为0.77（95%CI 0.74～0.79），特异度为0.84（95%CI 0.82～0.86），综合受试者工作特征曲线（SROC）计算曲线下面积（AUC）为0.894 2。结论　miR-208作为新型标志物，对AMI早期诊断具有较高的灵敏度和特异度，可协助临床早期诊断AMI。

关键词:

急性心肌梗死, miR-208, 早期诊断, meta分析