Abstract:

Objective　To analyze the correlation between non-high density lipoprotein cholesterol (non-HDL-C) level and cerebral infarction lesions. Methods　Sixty patients with cerebral infarction treated in Zhaoqing Hospital of Traditional Chinese Medicine from June 2020 to December 2022 were selected as a cerebral infarction group, and 60 volunteers without cerebral infarction who took medical examination during the same period as a control group. The total blood cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) in both groups were detected. The non-HDL-C and non-HDL-C to HDL-C ratio (non-HDL-C/HDL-C) were calculated. The general data, including gender, age and other factors, of the two groups were collected. The multivariate logistic regression analysis was performed and the receiver operating characteristic curves (ROC) were drawn to analyze the correlation between non-HDL-C, non-HDL-C/HDL-C, and cerebral infarction lesions. Results　The proportions of the elderly, smoking, drinking, hypertension, and diabetes and the levels of LDL-C, non-HDL-C, and non-HDL-C/HDL-C in the cerebral infarction group were higher than those in the control group, while the level of HDL-C in the cerebral infarction group was lower than that in the control group, with statistical differences (all P<0.05). Multivariate logistic regression analysis showed that age, hypertension history, high LDL-C level, low HDL-C level, high non-HDL-C level, and high non-HDL-C/HDL-C level were independent risk factors for cerebral infarction (all P<0.05). The areas under (AUC) the ROC's of non-HDL-C, non-HDL-C/HDL-C, and the combination in the diagnosis of cerebral infarction lesions were 0.797, 0.817, and 0.856 (all P<0.05); the sensitivities were 0.550, 0.617, and 0.800; the specificities were 0.933, 0.867, and 0.750, respectively. Conclusions　The level of non-HDL-C is closely related to the occurrence of cerebral infarction lesions. Non-HDL-C and non-HDL-C/HDL-C are factors influencing cerebral infarction lesions. Single tests and the combination have good diagnostic value for this disease.

Key words:

Cerebral infarction, HDL-C, Non-HDL-C, Non-HDL-C/HDL-C

摘要：

目的　分析非高密度脂蛋白胆固醇（non-HDL-C）水平与脑梗死病变的相关性。方法　选取2020年6月至2022年12月于肇庆市中医院就诊的60例脑梗死病变患者为脑梗死组［男32例，女28例，年龄（61.47±7.69）岁］，选取同期无脑梗死体检志愿者60名作为对照组［男31名，女29名，年龄（62.58±6.97）岁］，分别检测两组血总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C），计算non-HDL-C、non-HDL-C和HDL-C的比值（non-HDL-C/HDL-C）；收集两组性别、年龄等一般资料，进行多因素logistic回归分析，并绘制受试者工作特征曲线（ROC）分析non-HDL-C、non-HDL-C/HDL-C与脑梗死病变的相关性。结果　脑梗死组高龄、吸烟、饮酒、高血压、糖尿病比例和LDL-C、non-HDL-C、non-HDL-C/HDL-C水平均高于对照组，脑梗死组HDL-C水平低于对照组，差异均有统计学意义（均P<0.05）；多因素logistic回归分析结果显示，年龄、高血压、高LDL-C、低HDL-C水平、高non-HDL-C、高non-HDL-C/HDL-C水平为影响脑梗死的独立危险因素（均P<0.05）；non-HDL-C、non-HDL-C/HDL-C与联合检测诊断脑梗死病变的ROC下面积（AUC）分别为0.797、0.817、0.856（均P<0.05），灵敏度分别为0.550、0.617、0.800，特异度为0.933、0.867、0.750。结论　non-HDL-C水平与脑梗死病变的发生关系密切，non-HDL-C、non-HDL-C/HDL-C均为脑梗死病变的影响因素，单项与两项指标联合检测均对该疾病具有良好的诊断价值。

关键词:

脑梗死, HDL-C, non-HDL-C, non-HDL-C/HDL-C