Abstract:

Lung cancer is one of the malignant tumors with the highest mortality rate in the world, and the focus of chronic disease management in China. For patients with advanced lung cancer, radiotherapy, chemotherapy, and immunotherapy will increase the probability of pneumocystis infection. This paper reported a case of stage Ⅳ lung cancer patient who developed pulmonary infection after radiotherapy and chemotherapy combined with targeted drug therapy in Hunan Provincial People's Hospital in October 2020, who was diagnosed as Pneumocystis jirovecii pneumonia (PJP) by sputum next-generation sequencing (NGS). The diagnosis and treatment process of improvement after comprehensive management by the general practitioner team was analyzed and the relevant literatures were reviewed.

Key words:

Lung cancer, Pneumocystis jiroveci, Next-generation sequencing, General management

摘要：

肺癌是目前世界上病死率最高的恶性肿瘤之一，也是我国慢性病管理的重点之一。晚期肺癌患者由于进行放疗、化疗及免疫治疗等，合并肺孢子菌感染的机率增加。本文报道2020年10月湖南省人民医院收治的1例行放疗、化疗联合靶向药物治疗后出现肺部感染的肺癌Ⅳ期患者，经痰液二代测序，诊断为耶氏肺孢子菌肺炎，分析其在全科团队综合管理后好转的诊疗经过并复习相关文献。

关键词:

肺癌, 耶氏肺孢子菌, 二代测序, 综合管理