孕妇血清MIP-3α联合GATA3对胎膜早破并发宫内感染的评估价值

doi:10.3760/cma.j.cn441417-20240913-16002

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (16): 2647-2651.DOI: 10.3760/cma.j.cn441417-20240913-16002

孕妇血清MIP-3α联合GATA3对胎膜早破并发宫内感染的评估价值

王锡梅¹ 简婷婷¹ 仝晓玲² 栾丽霞³

¹西安国际医学中心医院产一科，西安 710000；²西安安琪儿妇产医院妇产科，西安 710000；³西安医学院第一附属医院妇产科，西安 710077

收稿日期:2024-09-13 出版日期:2025-08-15 发布日期:2025-08-28
通讯作者: 简婷婷，Email：741242271@qq.com
基金资助:
陕西省重点研发计划（2022SF-408）

Value of serum MIP-3α combined with GATA3 in evaluation of premature rupture of membranes complicated with intrauterine infection in pregnant women

Wang Ximei¹, Jian Tingting¹, Tong Xiaoling², Luan Lixia³

¹First Department of Obstetrics, Xi'an International Medical Center Hospital, Xi'an 710000, China; ²Department of Obstetrics and Gynecology, Xi'an Angel Maternity and Gynecology Hospital, Xi'an 710000, China; ³Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China

Received:2024-09-13 Online:2025-08-15 Published:2025-08-28
Contact: Jian Tingting, Email: 741242271@qq.com
Supported by:
Key Plan of Research and Development in Shaanxi (2022SF-408)

摘要/Abstract

摘要：

目的　探讨孕妇血清巨噬细胞炎性蛋白-3α（MIP-3α）联合GATA结合蛋白3（GATA3）对胎膜早破并发宫内感染的评估价值。方法　研究对象为西安国际医学中心医院2021年1月至2023年1月收治的121例胎膜早破孕妇，将其中发生宫内感染的35例设为观察组，未发生宫内感染的86例为对照组。收集所有孕妇的临床资料，检测孕妇产前血清中炎性因子［C反应蛋白（CRP）、降钙素原（PCT）、白细胞介素6（IL-6）］、MIP-3α和GATA3水平。采用独立样本t检验、χ²检验进行统计分析，logistic回归分析胎膜早破孕妇发生宫内感染的风险因素，并通过受试者操作特征曲线（ROC）评估MIP-3α联合GATA3检测在预测胎膜早破孕妇发生宫内感染中的诊断效能。结果　观察组产前血清CRP、PCT、IL-6、MIP-3α和GATA3水平分别为（20.23±3.41）mg/L、（10.15±2.03）μg/L、（8.31±2.76）μg/L、（47.02±6.13）ng/L、（263.41±28.61）μg/L，对照组分别为（11.13±3.12）mg/L、（5.97±1.34）μg/L、（4.89±1.03）μg/L、（25.63±4.20）ng/L、（301.39±32.28）μg/L，两组比较差异均有统计学意义（均P<0.05）。多因素分析结果表明，MIP-3α、GATA3是胎膜早破孕妇发生宫内感染的独立影响因素（均P<0.05）。ROC结果表明，MIP-3α联合GATA3检测对宫内感染的预测准确度为0.963。结论　胎膜早破孕妇产前血清MIP-3α、GATA-3水平增加可提高宫内感染的发生风险，联合检测可提高预测准确度。

关键词:

胎膜早破, 巨噬细胞炎性蛋白-3α, GATA结合蛋白, 宫内感染

Abstract:

Objective　To evaluate the value of serum macrophage inflammatory protein-3α (MIP-3α) combined with GATA binding protein 3 (GATA3) in the evaluation of premature rupture of membranes complicated with intrauterine infection in pregnant women. Methods　One hundred and twenty-two pregnant women with premature rupture of membranes treated at Xi'an International Medical Center Hospital from January 2021 to January 2023 were selected as the study objects. Among them, 35 patients who developed intrauterine infection were set as an observation group, while the rest 86 patients who did not develop intrauterine infection a control group. The clinical data of all the pregnant women were collected. The serum levels of inflammatory factors [C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6)], MIP-3α, and GATA3 in the pregnant women were measured before delivery. The independent-sample t test and χ² test were used for the statistical analysis. The logistic regression analysis was used to explore the risk factors of intrauterine infection in the women. The diagnostic efficacy of combined detection of MIP-3α and GATA3 in the prediction of intrauterine infection was evaluated using receiver operating characteristic curves (ROC). Results　The serum levels of CRP, PCT, IL-6, MIP-3α, and GATA3 before delivery in the observation group were (20.23±3.41) mg/L, (10.15±2.03) μg/L, (8.31±2.76) μg/L, (47.02±6.13) ng/L, and (263.41±28.61) μg/L, and the levels in the control group (11.13±3.12) mg/L, (5.97±1.34) μg/L, (4.89±1.03) μg/L, (25.63±4.20) ng/L, and (301.39±32.28) μg/L, with statistical differences between the two groups (all P<0.05). The multivariate analysis indicated that MIP-3α and GATA-3 were independent influencing factors for the occurrence of intrauterine infection (both P<0.05). The ROC results showed that the combined detection of MIP-3α and GATA-3 had a predictive accuracy of 0.963 for intrauterine infection. Conclusions　Increased levels of serum MIP-3α and GATA3 in pregnant women with premature rupture of membranes may increase the risk of intrauterine infections. The combination of these biomarkers can improve the accuracy for predicting such infections.

Key words:

Premature rupture of membranes, Macrophage inflammatory protein-3α, GATA binding protein, Intrauterine infection

王锡梅简婷婷仝晓玲栾丽霞.

孕妇血清MIP-3α联合GATA3对胎膜早破并发宫内感染的评估价值 [J]. 国际医药卫生导报, 2025, 31(16): 2647-2651.

Wang Ximei, Jian Tingting, Tong Xiaoling, Luan Lixia.

Value of serum MIP-3α combined with GATA3 in evaluation of premature rupture of membranes complicated with intrauterine infection in pregnant women [J]. International Medicine and Health Guidance News, 2025, 31(16): 2647-2651.

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孕妇血清MIP-3α联合GATA3对胎膜早破并发宫内感染的评估价值

Value of serum MIP-3α combined with GATA3 in evaluation of premature rupture of membranes complicated with intrauterine infection in pregnant women

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