基于NHANES数据库结果的血硒含量水平与脑卒中关系研究

doi:10.3760/cma.j.cn441417-20240722-14014

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (14): 2356-2360.DOI: 10.3760/cma.j.cn441417-20240722-14014

基于NHANES数据库结果的血硒含量水平与脑卒中关系研究

孙岭岭¹ 尤雪梅¹ 赵荣健¹ 孟军鹏¹ 刘丽娟¹ 韩斌²

¹西北大学第一医院神经内科，西安 710000；²山西省人民医院神经内科，太原 030000

收稿日期:2024-07-22 出版日期:2025-07-01 发布日期:2025-08-05
通讯作者: 韩斌，Email：hb29912@126.com
基金资助:
山西省基础研究计划（202303021221231）

Study of relationship between blood selenium level and stroke based on results of NHANES database

Sun Lingling¹, You Xuemei¹, Zhao Rongjian¹, Meng Junpeng¹, Liu Lijuan¹, Han Bin²

¹Department of Neurology, Northwest University First Hospital, Xi'an 710000, China; ²Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030000, China

Received:2024-07-22 Online:2025-07-01 Published:2025-08-05
Contact: Hanbin, Email: hb29912@126.com
Supported by:
Shanxi Province Basic Research Program (202303021221231)

摘要/Abstract

摘要：

目的　分析血硒含量与脑卒中的关系。方法　研究数据来自美国国家健康和营养检查研究（NHANES）数据库2015—2020年。经过筛选，7 677名参与者被纳入研究。使用多元回归模型检验血硒含量与脑卒中的关系，交互作用检验用于评估在不同亚组间的血硒含量与脑卒中的关系，采用t、χ²检验进行统计比较。结果　在7 677例参与者中，男3 954（51.50%）例，女3 723（48.50%）例；脑卒中369（4.81%）例，非脑卒中7 308（95.19%）例。对所有变量进行调整后，血硒含量与脑卒中的发生呈负相关，比值比（OR）=0.47，95%置信区间（CI）0.27～0.80，P=0.005 3。使用平滑曲线拟合来分析剂量-反应相关性，发现血硒含量与脑卒中之间存在线性负相关（P=0.011 3）。亚组分析结果表明，血硒含量与脑卒中之间的负相关在各亚组间具有稳定相关性。结论　在20岁及以上的美国人中，血硒含量水平与脑卒中的发生呈负相关。

关键词: 脑卒中, 血硒含量水平, NHANES数据库, 横断面研究

Abstract:

Objective　To analyze the relationship between blood selenium level and stroke. Methods　The data for the cross-sectional study were obtained from the National Health and Nutrition Examination Survey (NHANES) database of the United States from 2015 to 2020. After screening, 7 677 participants were included in this study. We examined the association between blood selenium and stroke using the multiple regression model. Interaction tests were used to assess the relationship between blood selenium and stroke in different subgroups. t and χ² tests were used for the statistical comparisons. Results　Among the 7 677 participants, there were 3 954 males (51.50%) and 3 723 females (48.50%). There were 369 cases (4.81%) of stroke and 7 308 (95.19%) cases of non-strokes. After adjusting all the variables, blood selenium was negatively correlated with stroke (OR=0.47, 95%CI 0.27-0.80, P=0.005 3). The dose-response correlation was analyzed using the smoothed curve fitting, and it revealed a linear negative correlation between blood selenium and stroke(P=0.011 3). The subgroup analyses showed that the negative correlation between blood selenium and stroke was stable between the subgroups. Conclusions　Blood selenium is negatively associated with the incidence of stroke in ≥20 years old Americans.

Key words: Stroke, , Blood selenium level, , NHANES database, , Cross-sectional study

孙岭岭尤雪梅赵荣健孟军鹏刘丽娟韩斌.

基于NHANES数据库结果的血硒含量水平与脑卒中关系研究 [J]. 国际医药卫生导报, 2025, 31(14): 2356-2360.

Sun Lingling, You Xuemei, Zhao Rongjian, Meng Junpeng, Liu Lijuan, Han Bin.

Study of relationship between blood selenium level and stroke based on results of NHANES database [J]. International Medicine and Health Guidance News, 2025, 31(14): 2356-2360.

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基于NHANES数据库结果的血硒含量水平与脑卒中关系研究

Study of relationship between blood selenium level and stroke based on results of NHANES database

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